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  1. 農学部
  1. 農学部
  2. 学術雑誌掲載論文 (農学部)

Characterization of lectin isolated from Momordica charantia seed as a B cell activator

http://hdl.handle.net/10458/2876
http://hdl.handle.net/10458/2876
e8368b88-d45e-4a5d-8c55-fd2e8d522536
名前 / ファイル ライセンス アクション
2876.pdf 2876.pdf (631.0 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2010-05-26
タイトル
タイトル Characterization of lectin isolated from Momordica charantia seed as a B cell activator
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
キーワード Momordica charantia seed lectin, B cell activator, T cell independent, BALB/c mice
資源タイプ
資源タイプ journal article
著者 Huang, Li

× Huang, Li

WEKO 4650

en Huang, Li

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Adachi, Takumi

× Adachi, Takumi

WEKO 4651

en Adachi, Takumi

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Shimizu, Yuya

× Shimizu, Yuya

WEKO 4614

en Shimizu, Yuya

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Goto, Yoshitaka

× Goto, Yoshitaka

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en Goto, Yoshitaka

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Toyama, Jun

× Toyama, Jun

WEKO 4654

en Toyama, Jun

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Tanaka, Hidenori

× Tanaka, Hidenori

WEKO 4740
e-Rad 50529253

en Tanaka, Hidenori

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Akashi, Ryo

× Akashi, Ryo

WEKO 1585
e-Rad 20253809

en Akashi, Ryo

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Sawaguchi, Akira

× Sawaguchi, Akira

WEKO 4657

en Sawaguchi, Akira

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Iwata, Hiroyuki

× Iwata, Hiroyuki

WEKO 4658

en Iwata, Hiroyuki

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Haga, Takeshi

× Haga, Takeshi

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en Haga, Takeshi

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抄録
内容記述タイプ Abstract
内容記述 Lectin isolated from the seeds of Momordica charantia (MCL) is a galactose-specific glycoprotein. To investigate the effects of MCL on cell activation, we analyzed the responses of BALB/c splenocytes, thymocytes, T cells and B cells on MCL stimulation. Proliferation assays showed that MCL selectively stimulates the B cell subset of splenocytes (p < 0.05) in a dose and time dependent manner and that this activation proceeds without the involvement of T cells. Flow cytometric analysis revealed that the fluorescein isothiocyanate (FITC)-labeled MCL binds to B cells, which was inhibited by specific sugars, including galactose. Mouse immunoglobulin (Ig) was able to inhibit MCL-induced proliferation of mouse B cells, suggesting MCL stimulates B cell activation via membrane Ig in the B cell surface. Moreover, after 96-h co-culture, MCL triggered splenocytes to produce a large amount of non-specific IgM in culture supernatants (p < 0.01). Additionally, MCL was shown to up-regulate the cell activation marker CD86, in a B cell subpopulation distinct from that affected by LPS. These data suggest that MCL is a T cell-independent B cell activator and a polyclonal Ig inducer, and provide further information on the immunomodulatory effect of MCL.
言語 en
書誌情報 en : Immunology letters

巻 121, 号 2, p. 148-156, 発行日 2008-12-22
出版者
出版者 Elsevier Science
言語 en
ISSN
収録物識別子タイプ ISSN
収録物識別子 01652478
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00231960
PubMed番号
関連タイプ isVersionOf
識別子タイプ PMID
関連識別子 19014972
著者版フラグ
出版タイプ AM
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Huang, Li, Adachi, Takumi, Shimizu, Yuya, Goto, Yoshitaka, Toyama, Jun, Tanaka, Hidenori, Akashi, Ryo, Sawaguchi, Akira, Iwata, Hiroyuki, Haga, Takeshi, 2008, Characterization of lectin isolated from Momordica charantia seed as a B cell activator: Elsevier Science, 148–156 p.

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