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ボロン酸置換ポルフィリンの糖認識特性
http://hdl.handle.net/10458/6400
http://hdl.handle.net/10458/6400afca3ad1-3540-4619-8acf-11ece8c48560
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | ボロン酸置換ポルフィリンの糖認識特性 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | Sugar-Recognition of Boronyl-Substituted Porphyrin | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Boronic acid, Sb-porphyrins, Saccharides, Absorption spectra, Fluorescence spectra, Mass spectra | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
松本, 仁
× 松本, 仁× 鈴木, 巧× 松本, 朋子× 保田, 昌秀× Mastumoto, Jin× Suzuki, Kou |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Porphyrins have received substantial attention in developing singlet oxygen (1O2) sensitizers for the photoinactivation of bacteria and for the photodynamic therapy (PDT) of tumor cells. Binding affinity of 1O2-sensitizer towards biomolecules such as DNA, protein, and saccharides is important for these biological applications. Especially, since cancer cells have a tendency to accumulate saccharides, the binding affinity of 1O2-sensitizer to tumor cells can be often enhanced by endowing the affinity towards saccharides. Here, we designed Sb-porphyrins (1a) incorporated axially with phenylboronic acid group, which can usually interact with cis-diol of saccharides. Actually the presence of glucose (3a), fructose (3b), and galactose (3c) caused to the spectral changes in absorption and fluorescence spectra as well as mass spectrometry of 1a due to the formation of an aggregate between 1a and 3. The binding constant (K) for the 1a–3b adduct were measured to be 1.39×10^5, 3.1×10^3, and 1.7×10^3 M^−1 by analysis of the absorption and the fluorescence spectral changes and the mass spectrometry, respectively. It was thought that the difference of these K values is dependent on the structure of the aggregates. Thus, it was found that 1a can highly associate with saccharides. | |||||
| 言語 | en | |||||
| 書誌情報 |
ja : 宮崎大学工学部紀要 en : Memoirs of Faculty of Engineering, University of Miyazaki 巻 47, p. 1-6, 発行日 2018-07 |
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| 出版者 | ||||||
| 出版者 | 宮崎大学工学部 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Faculty of Engineering, University of Miyazaki | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05404924 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00732558 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
