{"created":"2023-05-15T10:01:08.033068+00:00","id":5643,"links":{},"metadata":{"_buckets":{"deposit":"5a0cf565-e231-4464-bd5f-31c516f288e1"},"_deposit":{"created_by":5,"id":"5643","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"5643"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005643","sets":["73","73:36","73:36:330","73:36:330:328"]},"author_link":["6572","30302","6570","6574","30305","30306"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"宮崎大学工学部紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Memoirs of Faculty of Engineering, University of Miyazaki","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Porphyrins have received substantial attention in developing singlet oxygen (1O2) sensitizers for the photoinactivation of bacteria and for the photodynamic therapy (PDT) of tumor cells. Binding affinity of 1O2-sensitizer towards biomolecules such as DNA, protein, and saccharides is important for these biological applications. Especially, since cancer cells have a tendency to accumulate saccharides, the binding affinity of 1O2-sensitizer to tumor cells can be often enhanced by endowing the affinity towards saccharides. Here, we designed Sb-porphyrins (1a) incorporated axially with phenylboronic acid group, which can usually interact with cis-diol of saccharides. Actually the presence of glucose (3a), fructose (3b), and galactose (3c) caused to the spectral changes in absorption and fluorescence spectra as well as mass spectrometry of 1a due to the formation of an aggregate between 1a and 3. The binding constant (K) for the 1a–3b adduct were measured to be 1.39×10^5, 3.1×10^3, and 1.7×10^3 M^−1 by analysis of the absorption and the fluorescence spectral changes and the mass spectrometry, respectively. It was thought that the difference of these K values is dependent on the structure of the aggregates. Thus, it was found that 1a can highly associate with saccharides.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"宮崎大学工学部","subitem_publisher_language":"ja"},{"subitem_publisher":"Faculty of Engineering, University of Miyazaki","subitem_publisher_language":"en"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00732558","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05404924","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 仁","creatorNameLang":"ja"},{"creatorName":"マツモト, ジン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鈴木, 巧","creatorNameLang":"ja"},{"creatorName":"スズキ, コウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 朋子","creatorNameLang":"ja"},{"creatorName":"マツモト, トモコ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Tomoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"保田, 昌秀","creatorNameLang":"ja"},{"creatorName":"ヤスダ, マサヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Masahide","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mastumoto, Jin","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kou","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"p1-6_vol47.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://miyazaki-u.repo.nii.ac.jp/record/5643/files/p1-6_vol47.pdf"},"version_id":"3a110948-58c0-4135-a343-4ff76d4d5bc0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Boronic acid, Sb-porphyrins, Saccharides, Absorption spectra, Fluorescence spectra, Mass spectra","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ボロン酸置換ポルフィリンの糖認識特性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ボロン酸置換ポルフィリンの糖認識特性","subitem_title_language":"ja"},{"subitem_title":"Sugar-Recognition of Boronyl-Substituted Porphyrin","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"5","path":["73","36","330","328"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"5643","relation_version_is_last":true,"title":["ボロン酸置換ポルフィリンの糖認識特性"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-07-30T08:31:48.054156+00:00"}