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Hemokinin-1 mediates pruriceptive processing in the rat spinal cord
http://hdl.handle.net/10458/5435
http://hdl.handle.net/10458/54353a85e1c6-01f5-46c5-b55d-f4e440e3de3f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | Hemokinin-1 mediates pruriceptive processing in the rat spinal cord | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | pruritus, serotonin, histamine, [Leu^<11>]-hemokinin-1, spinal cord, rat | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
船橋, 英樹
× 船橋, 英樹× Naono-Nakayama, Rumi× 蛯原, 功介× 小金丸, 剛× 倉増, 亜紀× 池田, 哲也× 西森, 利數× 石田, 康 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hemokinin-1 （HK-1） is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P （SP）. Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu^<11>]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu^<11>]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu^<11>]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu^<11>]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu^<11>]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu^<11>]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu^<11>]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu^<11>]-SP, but not [Leu^<11>]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu^<11>]-HK-1 and [Leu^<11>]-SP on the induction of scratching behavior and c-Fos expression by serotonin （5-HT） and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu^<11>]-HK-1 and [Leu^<11>]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu^<11>]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Neuroscience 巻 277, p. 206–216-206–216, 発行日 2014-09 |
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| 出版者 | ||||||
| 出版者 | International Brain Research Organization | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03064522 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.neuroscience.2014.07.001 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
