{"created":"2023-05-15T10:00:16.128631+00:00","id":4586,"links":{},"metadata":{"_buckets":{"deposit":"fd0f74ee-231e-4a4d-9b34-268f20e6be5e"},"_deposit":{"created_by":5,"id":"4586","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"4586"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00004586","sets":["76","76:64"]},"author_link":["8704","24528","24680","9050","24524","24686","8383","24525"],"control_number":"4586","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"206–216","bibliographicPageStart":"206–216","bibliographicVolumeNumber":"277","bibliographic_titles":[{"bibliographic_title":"Neuroscience","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hemokinin-1 （HK-1） is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P （SP）. Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu^<11>]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu^<11>]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu^<11>]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu^<11>]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu^<11>]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu^<11>]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu^<11>]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu^<11>]-SP, but not [Leu^<11>]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu^<11>]-HK-1 and [Leu^<11>]-SP on the induction of scratching behavior and c-Fos expression by serotonin （5-HT） and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu^<11>]-HK-1 and [Leu^<11>]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu^<11>]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Brain Research Organization","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.neuroscience.2014.07.001","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03064522","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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ヤスシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Ishida","familyNameLang":"en"},{"familyName":"石田","familyNameLang":"ja"},{"familyName":"イシダ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Yasushi","givenNameLang":"en"},{"givenName":"康","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"8383","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20212897","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20212897"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pruritus, serotonin, histamine, [Leu^<11>]-hemokinin-1, spinal cord, rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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