@article{oai:miyazaki-u.repo.nii.ac.jp:00004586,
 author = {Funahashi, Hideki and 船橋, 英樹 and Naono-Nakayama, Rumi and 蛯原, 功介 and Ebihara, Kosuke and 小金丸, 剛 and Koganemaru, Go and 倉増, 亜紀 and Kuramashi, Aki and 池田, 哲也 and Ikeda, Tetsuya and Nishimori, Toshikazu and 西森, 利數 and Ishida, Yasushi and 石田, 康},
 journal = {Neuroscience},
 month = {Sep},
 note = {Hemokinin-1 （HK-1） is a new mammalian tachykinin peptide consisting of the amino acid sequence similar to substance P （SP）. Although the function of SP, a representative tachykinin peptide, has been well established in the pain system, that of HK-1 has not yet been elucidated. [Leu^<11>]-SP had an antagonistic effect on SP-induced scratching behavior, suggesting that [Leu^<11>]-HK-1 may also attenuate the induction of scratching behavior by HK-1. Thus, the effects of a pretreatment with [Leu^<11>]-HK-1 were evaluated to clarify the function of HK-1. The intrathecal administration of [Leu^<11>]-HK-1 attenuated the induction of scratching by HK-1, but not SP, while [Leu^<11>]-SP reduced the induction of scratching by SP, but not HK-1. These results indicated that [Leu^<11>]-HK-1 may be a more specific antagonist of HK-1-preferred receptors and [Leu^<11>]-SP has an antagonistic effect on the SP-preferred receptor, the neurokinin 1 receptor. In the formalin test for examining noxious response, the intrathecal administration of [Leu^<11>]-SP, but not [Leu^<11>]-HK-1, reduced the number of flinchings and c-Fos-positive cells in the spinal dorsal horn following formalin injection into the plantar region of the hind paw. These results indicated that SP, but not HK-1, is involved in nociceptive processing at the spinal level. To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu^<11>]-HK-1 and [Leu^<11>]-SP on the induction of scratching behavior and c-Fos expression by serotonin （5-HT） and histamine was evaluated. The increased induction of scratching behavior and c-Fos expression by 5-HT and histamine was markedly attenuated by pretreatment with both [Leu^<11>]-HK-1 and [Leu^<11>]-SP, suggesting that HK-1 and SP may be involved in pruritic processing. These results indicate that HK-1 is involved in pruritic processing and [Leu^<11>]-HK-1 is a valuable tool for clarifying the mechanisms underlying pruritic processing.},
 pages = {206–216--206–216},
 title = {Hemokinin-1 mediates pruriceptive processing in the rat spinal cord},
 volume = {277},
 year = {2014},
 yomi = {フナハシ, ヒデキ and エビハラ, コウスケ and コガネマル, ゴウ and クラマシ, アキ and イケダ, テツヤ and ニシモリ, トシカズ and イシダ, ヤスシ}
}