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Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats
http://hdl.handle.net/10458/5431
http://hdl.handle.net/10458/5431d53250fd-c05f-4c29-87a7-3929000fd81b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2020-06-21 | |||||||||||||||||
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| タイトル | Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Cabergoline, Rotigotine, Tacrine, Tremulous jaw movement, c-Fos, Parkinsonism | |||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||
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| アクセス権 | metadata only access | |||||||||||||||||
| 著者 |
小金丸, 剛
× 小金丸, 剛× 安部, 博史× 倉増, 亜紀× 蛯原, 功介× 松尾, 寿栄× 船橋, 英樹
WEKO
9050
× 保田, 和哉× 池田, 哲也× 西森, 利數
WEKO
24528
× 石田, 康× 小金丸, 剛× 安部, 博史× 倉増, 亜紀× 蛯原, 功介× 松尾, 寿栄× Yasuda, Kazuya× 池田, 哲也× Nishimori, Toshikazu |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Objectives:We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats. Methods:Rats received intraperitoneal injection of cabergoline （0.5, 1.0, or 5.0 mg/kg）, rotigotine （1.0, 2.5, or 10.0 mg/kg）, or vehicle 30 min before intraperitoneal injection of tacrine （5.0 mg/kg）. The number of tremulous jaw movements （TJMs） after tacrine administration was counted for 5 min. Animals were sacrificed 2 h later under deep anesthesia, and the brain sections were immunostained in order to evaluate the c-Fos expression. Results:Induction of TJMs by tacrine was dose-dependently reduced by pretreatment with cabergoline and rotigotine. The number of c-Fos-positive cells was significantly enhanced in the medial striatum, nucleus accumbens core, and nucleus accumbens shell after tacrine administration, and the enhanced expression of c-Fos in these three regions was significantly attenuated by cabergoline, while rotigotine suppressed c-Fos expression in two regions except the nucleus accumbens core. Conclusions:These results suggest that tacrine-induced TJMs would be relieved by either cabergoline or rotigotine and that anticholinesterase-induced TJMs and the ameliorating effects of dopamine agonists would relate to neuronal activation in the striatum and nucleus accumbens. |
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | 学位論文の一部を構成しているため、http://hdl.handle.net/10458/5430 に本文を掲載。 | |||||||||||||||||
| 書誌情報 |
Pharmacology Biochemistry and Behavior 巻 126, p. 103–108-103–108, 発行日 2014-09 |
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| 出版者 | Elsevier | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 00913057 | |||||||||||||||||
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| 識別子タイプ | HDL | |||||||||||||||||
| 関連識別子 | http://hdl.handle.net/10458/5430 | |||||||||||||||||
| 関連名称 | http://hdl.handle.net/10458/5430 | |||||||||||||||||
