@article{oai:miyazaki-u.repo.nii.ac.jp:00004582,
 author = {小金丸, 剛 and Koganemaru, Go and 安部, 博史 and Abe, Hiroshi and 倉増, 亜紀 and Kuramashi, Aki and 蛯原, 功介 and Ebihara, Kosuke and Matsuo, Hisae and 松尾, 寿栄 and 船橋, 英樹 and Funahashi, Hideki and 保田, 和哉 and 池田, 哲也 and Ikeda, Tetsuya and 西森, 利數 and Ishida, Yasushi and 石田, 康 and 小金丸, 剛 and Koganemaru, Go and 安部, 博史 and Abe, Hiroshi and 倉増, 亜紀 and Kuramashi, Aki and 蛯原, 功介 and Ebihara, Kosuke and Matsuo, Hisae and 松尾, 寿栄 and Yasuda, Kazuya and 池田, 哲也 and Ikeda, Tetsuya and Nishimori, Toshikazu},
 journal = {Pharmacology Biochemistry and Behavior},
 month = {Sep},
 note = {Objectives:We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats.
Methods:Rats received intraperitoneal injection of cabergoline （0.5, 1.0, or 5.0 mg/kg）, rotigotine （1.0, 2.5, or 10.0 mg/kg）, or vehicle 30 min before intraperitoneal injection of tacrine （5.0 mg/kg）. The number of tremulous jaw movements （TJMs） after tacrine administration was counted for 5 min. Animals were sacrificed 2 h later under deep anesthesia, and the brain sections were immunostained in order to evaluate the c-Fos expression.
Results:Induction of TJMs by tacrine was dose-dependently reduced by pretreatment with cabergoline and rotigotine. The number of c-Fos-positive cells was significantly enhanced in the medial striatum, nucleus accumbens core, and nucleus accumbens shell after tacrine administration, and the enhanced expression of c-Fos in these three regions was significantly attenuated by cabergoline, while rotigotine suppressed c-Fos expression in two regions except the nucleus accumbens core.
Conclusions:These results suggest that tacrine-induced TJMs would be relieved by either cabergoline or rotigotine and that anticholinesterase-induced TJMs and the ameliorating effects of dopamine agonists would relate to neuronal activation in the striatum and nucleus accumbens., 学位論文の一部を構成しているため、http://hdl.handle.net/10458/5430 に本文を掲載。},
 pages = {103–108--103–108},
 title = {Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats},
 volume = {126},
 year = {2014},
 yomi = {コガネマル, ゴウ and アベ, ヒロシ and クラマシ, アキ and エビハラ, コウスケ and マツオ, ヒサエ and フナハシ, ヒデキ and ヤスダ, カズヤ and イケダ, テツヤ and ニシモリ, トシカズ and イシダ, ヤスシ and コガネマル, ゴウ and アベ, ヒロシ and クラマシ, アキ and エビハラ, コウスケ and マツオ, ヒサエ and イケダ, テツヤ}
}