{"created":"2023-05-15T10:00:15.874533+00:00","id":4582,"links":{},"metadata":{"_buckets":{"deposit":"f2d37a58-b819-483f-b1f6-d733526fdaaa"},"_deposit":{"created_by":5,"id":"4582","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"4582"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00004582","sets":["72","72:30"]},"author_link":["8704","24662","24528","24680","9050","24652","24524","9110","8383","24664","9053","24525"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"103–108","bibliographicPageStart":"103–108","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"Pharmacology Biochemistry and Behavior"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives:We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats.\nMethods:Rats received intraperitoneal injection of cabergoline （0.5, 1.0, or 5.0 mg/kg）, rotigotine （1.0, 2.5, or 10.0 mg/kg）, or vehicle 30 min before intraperitoneal injection of tacrine （5.0 mg/kg）. The number of tremulous jaw movements （TJMs） after tacrine administration was counted for 5 min. Animals were sacrificed 2 h later under deep anesthesia, and the brain sections were immunostained in order to evaluate the c-Fos expression.\nResults:Induction of TJMs by tacrine was dose-dependently reduced by pretreatment with cabergoline and rotigotine. The number of c-Fos-positive cells was significantly enhanced in the medial striatum, nucleus accumbens core, and nucleus accumbens shell after tacrine administration, and the enhanced expression of c-Fos in these three regions was significantly attenuated by cabergoline, while rotigotine suppressed c-Fos expression in two regions except the nucleus accumbens core.\nConclusions:These results suggest that tacrine-induced TJMs would be relieved by either cabergoline or rotigotine and that anticholinesterase-induced TJMs and the ameliorating effects of dopamine agonists would relate to neuronal activation in the striatum and nucleus accumbens.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位論文の一部を構成しているため、http://hdl.handle.net/10458/5430 に本文を掲載。","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10458/5430"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/10458/5430","subitem_relation_type_select":"HDL"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00913057","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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