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Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro
http://hdl.handle.net/10458/5419
http://hdl.handle.net/10458/54193d0c3136-0267-4672-8286-5d4c7bfc28db
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2020-06-21 | |||||||||||||||||
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| タイトル | Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | NERP-2, Insulin secretion, Ca^<2+> | |||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||
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| アクセス権 | metadata only access | |||||||||||||||||
| 著者 |
Moin, Abu Saleh Md.
× Moin, Abu Saleh Md.× 山口, 秀樹
WEKO
21852
× Rhee, Marie× Kim, Ji-Wom× 十枝内, 厚次× Waise, T.M. Zaved× Naznin, Farhana× 松尾, 崇× 佐々木, 一樹× 南野, 直人× Yoon, Kun-Ho× 中里, 雅光
WEKO
21757
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Neuroendocrine regulatory peptide （NERP）-2, recently identified as a bioactive peptide involved in vasopressin secretion and feeding regulation in the central nervous system, is abundantly expressed in endocrine cells in peripheral tissues. To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. NERP-2 increased glucose-stimulated insulin secretion （GSIS） in a dose-dependent manner, with a lowest effective dose of 10^<−7> M, from the pancreatic β-cell line MIN6 and isolated mouse pancreatic islets. NERP-2 did not affect insulin secretion under the low-glucose conditions. Neither NERP-1 nor NERP-2-Gly （nonamidated NERP-2） stimulated insulin secretion. NERP-2 significantly augmented GSIS after intravenous administration to anesthetized rats or intraperitoneal injection to conscious mice. We detected NERP-2 in pancreatic islets, where it co-localized extensively with insulin. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings reveal that NERP-2 regulates GSIS by elevating intracellular calcium concentrations. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 428, 号 4, p. 512–517-512–517, 発行日 2012-11 |
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| 出版者 | Elsevier | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0006291X | |||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2012.10.073 | |||||||||||||||||
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| 出版タイプ | NA | |||||||||||||||||
