{"created":"2023-05-15T10:00:15.231286+00:00","id":4571,"links":{},"metadata":{"_buckets":{"deposit":"eec7f0ce-38d2-4782-9794-40070c977b30"},"_deposit":{"created_by":5,"id":"4571","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"4571"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00004571","sets":["76","76:64"]},"author_link":["24557","24554","24548","24556","21757","24545","21852","24561","24550","24546","24547","24553"],"control_number":"4571","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"512–517","bibliographicPageStart":"512–517","bibliographicVolumeNumber":"428","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuroendocrine regulatory peptide （NERP）-2, recently identified as a bioactive peptide involved in vasopressin secretion and feeding regulation in the central nervous system, is abundantly expressed in endocrine cells in peripheral tissues. To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. NERP-2 increased glucose-stimulated insulin secretion （GSIS） in a dose-dependent manner, with a lowest effective dose of 10^<−7> M, from the pancreatic β-cell line MIN6 and isolated mouse pancreatic islets. NERP-2 did not affect insulin secretion under the low-glucose conditions. Neither NERP-1 nor NERP-2-Gly （nonamidated NERP-2） stimulated insulin secretion. NERP-2 significantly augmented GSIS after intravenous administration to anesthetized rats or intraperitoneal injection to conscious mice. We detected NERP-2 in pancreatic islets, where it co-localized extensively with insulin. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings reveal that NERP-2 regulates GSIS by elevating intracellular calcium concentrations.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2012.10.073","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Moin, Abu Saleh Md.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Moin","familyNameLang":"en"}],"givenNames":[{"givenName":"Abu Saleh Md.","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24550","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山口, 秀樹","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"秀樹","givenNameLang":"ja"},{"givenName":"ヒデキ","givenNameLang":"ja-Kana"},{"givenName":"Hideki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21852","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10305097","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10305097"}]},{"creatorNames":[{"creatorName":"Rhee, Marie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Ji-Wom","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24554","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"十枝内, 厚次","creatorNameLang":"ja"},{"creatorName":"トシナイ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toshinai, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"十枝内","familyNameLang":"ja"},{"familyName":"トシナイ","familyNameLang":"ja-Kana"},{"familyName":"Toshinai","familyNameLang":"en"}],"givenNames":[{"givenName":"厚次","givenNameLang":"ja"},{"givenName":"コウジ","givenNameLang":"ja-Kana"},{"givenName":"Koji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24545","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Waise, T.M. Zaved","creatorNameLang":"en"}],"familyNames":[{"familyName":"Waise","familyNameLang":"en"}],"givenNames":[{"givenName":"T.M. Zaved","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24556","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Naznin, Farhana","creatorNameLang":"en"}],"familyNames":[{"familyName":"Naznin","familyNameLang":"en"}],"givenNames":[{"givenName":"Farhana","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松尾, 崇","creatorNameLang":"ja"},{"creatorName":"マツオ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuo, Takashi","creatorNameLang":"en"}],"familyNames":[{"familyName":"松尾","familyNameLang":"ja"},{"familyName":"マツオ","familyNameLang":"ja-Kana"},{"familyName":"Matsuo","familyNameLang":"en"}],"givenNames":[{"givenName":"崇","givenNameLang":"ja"},{"givenName":"タカシ","givenNameLang":"ja-Kana"},{"givenName":"Takashi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木, 一樹","creatorNameLang":"ja"},{"creatorName":"ササキ, カズキ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasaki, Kazuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"佐々木","familyNameLang":"ja"},{"familyName":"ササキ","familyNameLang":"ja-Kana"},{"familyName":"Sasaki","familyNameLang":"en"}],"givenNames":[{"givenName":"一樹","givenNameLang":"ja"},{"givenName":"カズキ","givenNameLang":"ja-Kana"},{"givenName":"Kazuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南野, 直人","creatorNameLang":"ja"},{"creatorName":"ミナミノ, ナオト","creatorNameLang":"ja-Kana"},{"creatorName":"Minamino, Naoto","creatorNameLang":"en"}],"familyNames":[{"familyName":"南野","familyNameLang":"ja"},{"familyName":"ミナミノ","familyNameLang":"ja-Kana"},{"familyName":"Minamino","familyNameLang":"en"}],"givenNames":[{"givenName":"直人","givenNameLang":"ja"},{"givenName":"ナオト","givenNameLang":"ja-Kana"},{"givenName":"Naoto","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoon, Kun-Ho","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"24561","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"中里, 雅光","creatorNameLang":"ja"},{"creatorName":"ナカザト, マサミツ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakazato, Masamitsu","creatorNameLang":"en"}],"familyNames":[{"familyName":"中里","familyNameLang":"ja"},{"familyName":"ナカザト","familyNameLang":"ja-Kana"},{"familyName":"Nakazato","familyNameLang":"en"}],"givenNames":[{"givenName":"雅光","givenNameLang":"ja"},{"givenName":"マサミツ","givenNameLang":"ja-Kana"},{"givenName":"Masamitsu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21757","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10180267","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10180267"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NERP-2, Insulin secretion, Ca^<2+>","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"4571","relation_version_is_last":true,"title":["Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-14T05:44:41.686435+00:00"}