@article{oai:miyazaki-u.repo.nii.ac.jp:00004571,
 author = {Moin, Abu Saleh Md. and Yamaguchi, Hideki and 山口, 秀樹 and Rhee, Marie and Kim, Ji-Wom and 十枝内, 厚次 and Toshinai, Koji and Waise, T.M. Zaved and Naznin, Farhana and 松尾, 崇 and Matsuo, Takashi and 佐々木, 一樹 and Sasaki, Kazuki and 南野, 直人 and Minamino, Naoto and Yoon, Kun-Ho and Nakazato, Masamitsu and 中里, 雅光},
 issue = {4},
 journal = {Biochemical and Biophysical Research Communications},
 month = {Nov},
 note = {Neuroendocrine regulatory peptide （NERP）-2, recently identified as a bioactive peptide involved in vasopressin secretion and feeding regulation in the central nervous system, is abundantly expressed in endocrine cells in peripheral tissues. To explore the physiological roles of NERP-2 in the pancreas, we examined its effects on insulin secretion. NERP-2 increased glucose-stimulated insulin secretion （GSIS） in a dose-dependent manner, with a lowest effective dose of 10^<−7> M, from the pancreatic β-cell line MIN6 and isolated mouse pancreatic islets. NERP-2 did not affect insulin secretion under the low-glucose conditions. Neither NERP-1 nor NERP-2-Gly （nonamidated NERP-2） stimulated insulin secretion. NERP-2 significantly augmented GSIS after intravenous administration to anesthetized rats or intraperitoneal injection to conscious mice. We detected NERP-2 in pancreatic islets, where it co-localized extensively with insulin. Calcium-imaging analysis demonstrated that NERP-2 increased the calcium influx in MIN6 cells. These findings reveal that NERP-2 regulates GSIS by elevating intracellular calcium concentrations.},
 pages = {512–517--512–517},
 title = {Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro},
 volume = {428},
 year = {2012},
 yomi = {ヤマグチ, ヒデキ and トシナイ, コウジ and マツオ, タカシ and ササキ, カズキ and ミナミノ, ナオト and ナカザト, マサミツ}
}