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Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats
http://hdl.handle.net/10458/5416
http://hdl.handle.net/10458/541678740517-c222-488b-8d30-860f64069561
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Blonanserin, Haloperidol, Latent inhibition, Immediate-early gene protein, Schizophrenia | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
倉増, 亜紀
× 倉増, 亜紀× 安部, 博史× 小金丸, 剛× 松尾, 寿栄× 池田, 哲也× 蛯原, 功介× 船橋, 英樹× 武田, 龍一郎× 西森, 利數× 石田, 康 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition （LI） and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone （conditioned stimulus） was paired with a mild foot shock （unconditioned stimulus）. This paradigm was presented to rats licking water. Methamphetamine-induced （1.0 mg/kg, i.p.） disruption of LI was significantly improved by the administration of a higher dose （3.0 mg/kg, i.p.） of blonanserin and tended to be improved by 1.0-mg/kg blonanserin and 0.2-mg/kg haloperidol but not by a lower dose （0.3 mg/kg） of blonanserin. Immunohistochemical examination showed blonanserin （3.0 mg/kg, i.p.） increased c-Fos expression in the shell area but not in the core area of the nucleus accumbens while methamphetamine （3.0 mg/kg, i.p.） produced the opposite expression pattern. Blonanserin also increased the number of c-Fos expressions in the central amygdala nucleus but not in the basolateral amygdala nucleus or the prefrontal cortex. Blonanserin ameliorates the methamphetamine-induced disruption of LI, as other antipsychotics do, and a neuronal activation and/or modulation of neurotransmission in the nucleus accumbens is related to the disruption of LI by methamphetamine and to its amelioration by blonanserin. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Neuroscience Letters 巻 549, p. 97–102-97–102, 発行日 2013-08 |
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| 出版者 | ||||||
| 出版者 | Elsevier Ireland | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03043940 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.neulet.2013.06.020 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
