{"created":"2023-05-15T10:00:15.039241+00:00","id":4568,"links":{},"metadata":{"_buckets":{"deposit":"93489af0-96f2-4b93-b43d-b766b070a522"},"_deposit":{"created_by":5,"id":"4568","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"4568"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00004568","sets":["76","76:64"]},"author_link":["8704","24528","24680","9050","24524","8632","9110","8383","9053","24525"],"control_number":"4568","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"97–102","bibliographicPageStart":"97–102","bibliographicVolumeNumber":"549","bibliographic_titles":[{"bibliographic_title":"Neuroscience Letters","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition （LI） and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone （conditioned stimulus） was paired with a mild foot shock （unconditioned stimulus）. This paradigm was presented to rats licking water. Methamphetamine-induced （1.0 mg/kg, i.p.） disruption of LI was significantly improved by the administration of a higher dose （3.0 mg/kg, i.p.） of blonanserin and tended to be improved by 1.0-mg/kg blonanserin and 0.2-mg/kg haloperidol but not by a lower dose （0.3 mg/kg） of blonanserin. Immunohistochemical examination showed blonanserin （3.0 mg/kg, i.p.） increased c-Fos expression in the shell area but not in the core area of the nucleus accumbens while methamphetamine （3.0 mg/kg, i.p.） produced the opposite expression pattern. Blonanserin also increased the number of c-Fos expressions in the central amygdala nucleus but not in the basolateral amygdala nucleus or the prefrontal cortex. Blonanserin ameliorates the methamphetamine-induced disruption of LI, as other antipsychotics do, and a neuronal activation and/or modulation of neurotransmission in the nucleus accumbens is related to the disruption of LI by methamphetamine and to its amelioration by blonanserin.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.neulet.2013.06.020","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03043940","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only 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Schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"4568","relation_version_is_last":true,"title":["Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2025-01-15T02:06:03.051177+00:00"}