@article{oai:miyazaki-u.repo.nii.ac.jp:00004568,
 author = {倉増, 亜紀 and Kuramashi, Aki and 安部, 博史 and Abe, Hiroshi and 小金丸, 剛 and Koganemaru, Go and Matsuo, Hisae and 松尾, 寿栄 and 池田, 哲也 and Ikeda, Tetsuya and 蛯原, 功介 and Ebihara, Kosuke and Funahashi, Hideki and 船橋, 英樹 and Takeda, Ryuichiro and 武田, 龍一郎 and Nishimori, Toshikazu and 西森, 利數 and Ishida, Yasushi and 石田, 康},
 journal = {Neuroscience Letters},
 month = {Aug},
 note = {To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition （LI） and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone （conditioned stimulus） was paired with a mild foot shock （unconditioned stimulus）. This paradigm was presented to rats licking water. Methamphetamine-induced （1.0 mg/kg, i.p.） disruption of LI was significantly improved by the administration of a higher dose （3.0 mg/kg, i.p.） of blonanserin and tended to be improved by 1.0-mg/kg blonanserin and 0.2-mg/kg haloperidol but not by a lower dose （0.3 mg/kg） of blonanserin. Immunohistochemical examination showed blonanserin （3.0 mg/kg, i.p.） increased c-Fos expression in the shell area but not in the core area of the nucleus accumbens while methamphetamine （3.0 mg/kg, i.p.） produced the opposite expression pattern. Blonanserin also increased the number of c-Fos expressions in the central amygdala nucleus but not in the basolateral amygdala nucleus or the prefrontal cortex. Blonanserin ameliorates the methamphetamine-induced disruption of LI, as other antipsychotics do, and a neuronal activation and/or modulation of neurotransmission in the nucleus accumbens is related to the disruption of LI by methamphetamine and to its amelioration by blonanserin.},
 pages = {97–102--97–102},
 title = {Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats},
 volume = {549},
 year = {2013},
 yomi = {クラマシ, アキ and アベ, ヒロシ and コガネマル, ゴウ and マツオ, ヒサエ and イケダ, テツヤ and エビハラ, コウスケ and フナハシ, ヒデキ and タケダ, リュウイチロウ and ニシモリ, トシカズ and イシダ, ヤスシ}
}