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実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響
http://hdl.handle.net/10458/4264
http://hdl.handle.net/10458/4264cddbe0e0-1c8d-46b5-a434-6cfb25513c0d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
kita1991.pdf (15.2 MB)
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| Item type | その他 / Others(1) | |||||
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| 公開日 | 2012-12-27 | |||||
| タイトル | ||||||
| タイトル | EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | brain natriuretic peptide, atrial natriuretic peptide, blood pressure, natriuresis, metabolic clearance rate, rat | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
北, 俊弘
× 北, 俊弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recently rat brain natriuretic peptide-45（rat BNP-45） was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats （SHR） and Wistar-Kyoto rats （WKY）, and compared them with those of rat a-atrial natriuretic peptide（a-ANP）. BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose （2.0 nmol/kg） of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides （2.0μg） were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged. | |||||
| 言語 | en | |||||
| 書誌情報 |
発行日 1991-03 |
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北, 俊弘, 1991, 実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響.
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