@misc{oai:miyazaki-u.repo.nii.ac.jp:00003875,
 author = {Kita, Toshihiro and 北, 俊弘},
 month = {Mar},
 note = {Recently rat brain natriuretic peptide-45（rat BNP-45） was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats （SHR） and Wistar-Kyoto rats （WKY）, and compared them with those of rat a-atrial natriuretic peptide（a-ANP）. BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose （2.0 nmol/kg） of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides （2.0μg） were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged.},
 title = {EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS},
 year = {1991},
 yomi = {キタ, トシヒロ}
}