{"created":"2023-05-15T09:59:40.649937+00:00","id":3875,"links":{},"metadata":{"_buckets":{"deposit":"43788ee6-d6a9-47e8-9c23-0eaeb2081dd2"},"_deposit":{"created_by":9,"id":"3875","owner":"5","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"3875"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00003875","sets":["72","72:54"]},"author_link":["8181"],"item_10010_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"}}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently rat brain natriuretic peptide-45（rat BNP-45） was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats （SHR） and Wistar-Kyoto rats （WKY）, and compared them with those of rat a-atrial natriuretic peptide（a-ANP）. BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose （2.0 nmol/kg） of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides （2.0μg） were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kita, Toshihiro","creatorNameLang":"en"},{"creatorName":"北, 俊弘","creatorNameLang":"ja"},{"creatorName":"キタ, トシヒロ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"kita1991.pdf","filesize":[{"value":"15.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kita1991.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/3875/files/kita1991.pdf"},"version_id":"2ff1bc6b-cc94-4eba-bc26-169ac7adb719"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"brain natriuretic peptide, atrial natriuretic peptide, blood pressure, natriuresis, metabolic clearance rate, rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS","subitem_title_language":"en"},{"subitem_title":"実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響","subitem_title_language":"ja"}]},"item_type_id":"10010","owner":"9","path":["72","54"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-12-27"},"publish_date":"2012-12-27","publish_status":"0","recid":"3875","relation_version_is_last":true,"title":["EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-01-30T04:28:26.667479+00:00"}