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Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina
http://hdl.handle.net/10458/1094
http://hdl.handle.net/10458/109479f489d6-f36c-4a1f-99f7-b3baa583ae5e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
thrombosisresearch asada 2007-121(2).pdf (389.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-01-16 | |||||
| タイトル | ||||||
| タイトル | Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Angina pectoris, Atherectomy, Atherothrombosis, Immunohistochemistry, Interleukin-18 | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
浅田, 祐士郎
× 浅田, 祐士郎× Nishihira, Kensaku× 今村, 卓郎× Hatakeyama, Kinta× 山下, 篤× Shibata, Yoshisato× Date, Haruhiko× Manabe, Ichiro× Nagai, Ryozo× 北村, 和雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interleukin （IL）-18 plays a central role in the inflammatory cascade. We immunohistochemically assessed specimens obtained by directional coronary atherectomy （DCA） from patients with stable and unstable angina to determine whether IL-18 expression in coronary atherosclerotic lesions is related to plaque instability. We detected IL-18 immunoreactivity in coronary culprit plaques, especially in macrophages. More areas were immunopositive for IL-18 in DCA specimens from patients with unstable angina than in those with stable angina and IL-18 expression was increased in plaques containing thrombus. Furthermore, IL-18 expression significantly correlated with IFN-ホウ expression. These findings suggest that IL-18 is involved in the pathogenesis of plaque instability in human coronary arteries. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.elsevier.com/wps/find/journaldescription.cws_home/369/description | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Thrombosis research 巻 121, 号 2, p. 275-279, 発行日 2007 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00493848 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00863148 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
