@article{oai:miyazaki-u.repo.nii.ac.jp:00001531, author = {Asada, Yujiro and 浅田, 祐士郎 and Nishihira, Kensaku and 今村, 卓郎 and Imamura, Takuroh and Hatakeyama, Kinta and Yamashita, Atsushi and 山下, 篤 and Shibata, Yoshisato and Date, Haruhiko and Manabe, Ichiro and Nagai, Ryozo and Kitamura, Kazuo and 北村, 和雄}, issue = {2}, journal = {Thrombosis research}, month = {}, note = {Interleukin (IL)-18 plays a central role in the inflammatory cascade. We immunohistochemically assessed specimens obtained by directional coronary atherectomy (DCA) from patients with stable and unstable angina to determine whether IL-18 expression in coronary atherosclerotic lesions is related to plaque instability. We detected IL-18 immunoreactivity in coronary culprit plaques, especially in macrophages. More areas were immunopositive for IL-18 in DCA specimens from patients with unstable angina than in those with stable angina and IL-18 expression was increased in plaques containing thrombus. Furthermore, IL-18 expression significantly correlated with IFN-ホウ expression. These findings suggest that IL-18 is involved in the pathogenesis of plaque instability in human coronary arteries., http://www.elsevier.com/wps/find/journaldescription.cws_home/369/description}, pages = {275--279}, title = {Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina}, volume = {121}, year = {2007}, yomi = {アサダ , ユウジロウ and イマムラ, タクロウ and ヤマシタ, アツシ and キタムラ, カズオ} }