WEKO3
アイテム
Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy
http://hdl.handle.net/10458/00010506
http://hdl.handle.net/10458/000105069363fb5e-1ef8-42d0-90fd-126a5702f1ed
| 名前 / ファイル | ライセンス | アクション |
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本文 (57.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2023-02-20 | |||||||||||||||||
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| タイトル | Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| キーワード | IgA nephropathy | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | serum IgA/C3 ratio | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | serum IgA | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | complement | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | hematuria | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
小松, 弘幸
× 小松, 弘幸
WEKO
7768
× 藤元, 昭一
WEKO
8142
× 原, 誠一郎× 佐藤, 祐二× 山田, 和弘× 江藤, 胤尚 |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Objective: The serum IgA/C3 ratio might be considered to serve as a diagnostic marker for patients with IgA nephropathy （IgAN）, but its value as a marker of the severity of histological lesions or prognosis is unknown. | |||||||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Methods: We studied the serum IgA/C3 ratio, using standardized reference material, in 86 patients with IgAN and in 32 with non-IgAN. The patients with IgAN were divided according to the severity of histological lesions （mild IgAN, n=29 and severe IgAN, n=57） based on Japanese clinical guidelines. | |||||||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Results: The serum IgA level was significantly higher, while its C3 level was lower in patients with severe IgAN compared to those with non-IgAN. However, these levels were not different between patients with mild IgAN and non-IgAN. In contrast, the serum IgA/C3 ratio obviously differed among the three groups （2.47+/-0.96 vs. 3.63+/-1.44 vs. 4.72+/-1.86; p<0.01, ANOVA）. Kaplan-Meier analysis of the patients with IgAN classified according to the mean serum IgA/C3 ratio revealed that the group with high serum IgA/C3 （4.5 and above） had a significantly poorer renal outcome （p<0.05, log-rank test）, since the cumulative renal survival rate at 5 years was 84.4% vs. 100%. The ratio （%） of patients with severe IgAN in whom hematuria disappeared, was significantly higher in the low, than in the high serum IgA/C3 group （41.9% vs. 15.4%; p<0.05, t-test）. | |||||||||||||||||
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| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Conclusion: The serum IgA/C3 ratio appears to reflect the histological severity of IgAN and could serve as a marker of the progression of IgAN. | |||||||||||||||||
| 書誌情報 |
en : Internal medicine (Tokyo, Japan) 巻 43, 号 11, p. 1023-1028, 発行日 2004-11 |
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| 出版者 | Japanese Society of Internal Medicine | |||||||||||||||||
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| 収録物識別子 | 09182918 | |||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||||
| 関連識別子 | 15609695 | |||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.2169/internalmedicine.43.1023 | |||||||||||||||||
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| 権利情報 | © 2004 by The Japanese Society of Internal Medicine | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||
