{"created":"2023-05-15T10:01:57.938984+00:00","id":6655,"links":{},"metadata":{"_buckets":{"deposit":"5a4655a0-9c3b-4c8c-9513-8485ef659619"},"_deposit":{"created_by":5,"id":"6655","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"6655"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00006655","sets":["72","72:30"]},"author_link":["8160","8140","8139","7768","8158","8142"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"1028","bibliographicPageStart":"1023","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Internal medicine (Tokyo, Japan)","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The serum IgA/C3 ratio might be considered to serve as a diagnostic marker for patients with IgA nephropathy （IgAN）, but its value as a marker of the severity of histological lesions or prognosis is unknown.","subitem_description_type":"Abstract"},{"subitem_description":"Methods: We studied the serum IgA/C3 ratio, using standardized reference material, in 86 patients with IgAN and in 32 with non-IgAN. The patients with IgAN were divided according to the severity of histological lesions （mild IgAN, n=29 and severe IgAN, n=57） based on Japanese clinical guidelines.","subitem_description_type":"Abstract"},{"subitem_description":"Results: The serum IgA level was significantly higher, while its C3 level was lower in patients with severe IgAN compared to those with non-IgAN. However, these levels were not different between patients with mild IgAN and non-IgAN. In contrast, the serum IgA/C3 ratio obviously differed among the three groups （2.47+/-0.96 vs. 3.63+/-1.44 vs. 4.72+/-1.86; p<0.01, ANOVA）. Kaplan-Meier analysis of the patients with IgAN classified according to the mean serum IgA/C3 ratio revealed that the group with high serum IgA/C3 （4.5 and above） had a significantly poorer renal outcome （p<0.05, log-rank test）, since the cumulative renal survival rate at 5 years was 84.4% vs. 100%. The ratio （%） of patients with severe IgAN in whom hematuria disappeared, was significantly higher in the low, than in the high serum IgA/C3 group （41.9% vs. 15.4%; p<0.05, t-test）.","subitem_description_type":"Abstract"},{"subitem_description":"Conclusion: The serum IgA/C3 ratio appears to reflect the histological severity of IgAN and could serve as a marker of the progression of IgAN.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Internal Medicine"}]},"item_10001_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"15609695","subitem_relation_type_select":"PMID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.2169/internalmedicine.43.1023","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2004 by The Japanese Society of Internal Medicine"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09182918","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"小松, 弘幸","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, 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nephropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum IgA/C3 ratio","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"serum IgA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"complement","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hematuria","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between Serum IgA/C3 Ratio and Progression of IgA Nephropathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between Serum IgA/C3 Ratio and Progression of IgA 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