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Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes
http://hdl.handle.net/10458/00010380
http://hdl.handle.net/10458/00010380ef2f7f62-2499-411a-8572-fd4ac788c226
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1-s2.0-S0006291X22006027-main (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2022-05-11 | |||||
| タイトル | ||||||
| タイトル | Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | SARS-CoV-2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Roanthocyanidins | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Blueberry | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Angiotensin II converting Enzyme | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Viral chymotrypsin-like cysteine protease (3CLpro) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
菅本, 和寛
× 菅本, 和寛× 齊藤, 暁× 岡林, 環樹× 國武, 久登× 森下, 和広× Tanaka, Yuri L.× Saito, Akatsuki× Goto, Yoh× Nakayama, Takayuki× Okabayashi, Tamaki× Morishita, Kazuhiro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | With the current worldwide pandemic of COVID-19, there is an urgent need to develop effective treatment and prevention methods against SARS-CoV-2 infection. We have previously reported that the proanthocyanidin （PAC） fraction in blueberry （BB） leaves has strong antiviral activity against hepatitis C virus （HCV） and human T-lymphocytic leukemia virus type 1 （HTLV-1）. In this study, we used Kunisato 35 Gou （K35） derived from the rabbit eye blueberry （Vaccinium virgatum Aiton）, which has a high PAC content in the leaves and stems. The mean of polymerization （mDP） of PAC in K35 was the highest of 7.88 in Fraction 8 （Fr8） from the stems and 12.28 of Fraction 7 （Fr7） in the leaves. The composition of BB-PAC in K35 is that most are B-type bonds with a small number of A-type bonds and cinchonain I as extension units. A strong antiviral effect was observed in Fr7, with a high polymerized PAC content in both the leaves and stems. Furthermore, when we examined the difference in the action of BB-PAC before and after SARS-CoV-2 infection, we found a stronger inhibitory effect in the pre-infection period. Moreover, BB-PAC Fr7 inhibited the activity of angiotensin II converting enzyme （ACE2）, although no effect was observed in a neutralization test of pseudotyped SARS-CoV-2. The viral chymotrypsin-like cysteine protease （3CLpro） of SARS-CoV-2 was also inhibited by BB-PAC Fr7 in leaves and stems. These results indicate that BB-PAC has at least two different inhibitory effects, and that it is effective in suppressing SARS-CoV-2 infection regardless of the time of infection. | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 号 615, p. 56-62, 発行日 2022-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006291X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2022.04.072 | |||||
| 権利 | ||||||
| 権利情報 | © 2022 The Authors. Published by Elsevier Inc. | |||||
