| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-05-11 |
| タイトル |
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タイトル |
Highly polymerized proanthocyanidins (PAC) components from blueberry leaf and stem significantly inhibit SARS-CoV-2 infection via inhibition of ACE2 and viral 3CLpro enzymes |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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キーワード |
SARS-CoV-2 |
| キーワード |
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言語 |
en |
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キーワード |
Roanthocyanidins |
| キーワード |
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言語 |
en |
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キーワード |
Blueberry |
| キーワード |
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言語 |
en |
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キーワード |
Angiotensin II converting Enzyme |
| キーワード |
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言語 |
en |
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キーワード |
Viral chymotrypsin-like cysteine protease (3CLpro) |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
菅本, 和寛
WEKO
5752
e-Rad_Researcher
10274771
| ja |
菅本, 和寛
宮崎大学
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| ja-Kana |
スガモト, カズヒロ
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| en |
Sugamoto, Kazuhiro
University of Miyazaki
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Search repository
Tanaka, Yuri L.
齊藤, 暁
WEKO
33890
e-Rad_Researcher
30621792
| ja |
齊藤, 暁
宮崎大学
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| ja-Kana |
サイトウ, アカツキ
|
| en |
Saito, Akatsuki
University of Miyazaki
|
Search repository
Goto, Yoh
Nakayama, Takayuki
岡林, 環樹
WEKO
33891
e-Rad_Researcher
10359995
| ja |
岡林, 環樹
宮崎大学
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| ja-Kana |
オカバヤシ, タマキ
|
| en |
Okabayashi, Tamaki
University of Miyazaki
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Search repository
國武, 久登
WEKO
1631
e-Rad_Researcher
80289628
| ja |
國武, 久登
宮崎大学
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| ja-Kana |
クニタケ, ヒサト
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| en |
Kunitake, Hisato
University of Miyazaki
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Search repository
森下, 和広
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
With the current worldwide pandemic of COVID-19, there is an urgent need to develop effective treatment and prevention methods against SARS-CoV-2 infection. We have previously reported that the proanthocyanidin （PAC） fraction in blueberry （BB） leaves has strong antiviral activity against hepatitis C virus （HCV） and human T-lymphocytic leukemia virus type 1 （HTLV-1）. In this study, we used Kunisato 35 Gou （K35） derived from the rabbit eye blueberry （Vaccinium virgatum Aiton）, which has a high PAC content in the leaves and stems. The mean of polymerization （mDP） of PAC in K35 was the highest of 7.88 in Fraction 8 （Fr8） from the stems and 12.28 of Fraction 7 （Fr7） in the leaves. The composition of BB-PAC in K35 is that most are B-type bonds with a small number of A-type bonds and cinchonain I as extension units. A strong antiviral effect was observed in Fr7, with a high polymerized PAC content in both the leaves and stems. Furthermore, when we examined the difference in the action of BB-PAC before and after SARS-CoV-2 infection, we found a stronger inhibitory effect in the pre-infection period. Moreover, BB-PAC Fr7 inhibited the activity of angiotensin II converting enzyme （ACE2）, although no effect was observed in a neutralization test of pseudotyped SARS-CoV-2. The viral chymotrypsin-like cysteine protease （3CLpro） of SARS-CoV-2 was also inhibited by BB-PAC Fr7 in leaves and stems. These results indicate that BB-PAC has at least two different inhibitory effects, and that it is effective in suppressing SARS-CoV-2 infection regardless of the time of infection. |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
号 615,
p. 56-62,
発行日 2022-07
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006291X |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2022.04.072 |
| 権利 |
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権利情報 |
© 2022 The Authors. Published by Elsevier Inc. |
| 著者版フラグ |
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出版タイプ |
VoR |
1-s2.0-S0006291X22006027-main (1.3 MB)
