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Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet
http://hdl.handle.net/10458/3528
http://hdl.handle.net/10458/352855ea5683-0415-479b-9358-b9f2534e5e18
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
FN_880.pdf (805.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-12-02 | |||||
| タイトル | ||||||
| タイトル | Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Threonine imbalance, Fatty acid metabolism, Ketone body production, Triglyceride secretion, Liver perfusion | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
福田, 亘博
× 福田, 亘博× 日高, 敏郎× 戸田, 隆義× 菅野, 道廣× Hidaka, Toshiro× Toda, Takayoshi× 菅野, 道廣 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of a threonine-imbalanced diet （8% casein supplemented with 0.3% methionine, TI） on the ketone body production and the secretion rate of lipids were examined in the isolated perfused rat liver. Feeding a TI diet compared to an 8% casein （C） diet resulted in an enlargement of liver, presumably due to 2-4-fold accumulation of triglyceride. Serum triglyceride likewise increased significantly in rats fed a TI diet. No significant difference was found in the other lipid components both in serum and liver. When the livers from rats fed C or TI diets were isolated and perfused in the presence of an exogenous oleate substrate, the TI diet decreased the ketone body production and conversely increased the secretion rate of triglyceride, suggesting an inverse relationship between rates of ketogenesis and triglyceride secretion. The proportion of oleate in the perfusate triglyceride obtained at the end of perfusion was comparable between the C and TI groups, whereas in the post-perfused liver it was higher in the former than in the latter, suggesting a stimulatory effect of the TI diet on the secretion of the oleate in the form of triglyceride. These results indicate that altered hepatic metabolism of long-chain free fatty acids between the pathways of oxidation and esterification is one of the causative factors for triglyceride accumulation in the liver produced by threonine imbalance. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 36, 号 5, p. 467-474, 発行日 1990-10 |
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| 出版者 | ||||||
| 出版者 | The Vitamin Society of Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03014800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 本文データは学協会の許諾に基づきJournal@rchiveから複製したものである | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://dx.doi.org/10.3177/jnsv.36.467 | |||||
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Cite as
福田, 亘博, 日高, 敏郎, 戸田, 隆義, 菅野, 道廣, Hidaka, Toshiro, Toda, Takayoshi, 菅野, 道廣, 1990, Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet: 日本ビタミン学会, 467–474 p.
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