{"created":"2023-05-15T09:56:51.961370+00:00","id":583,"links":{},"metadata":{"_buckets":{"deposit":"2100587c-d119-46ea-a78d-388fca237611"},"_deposit":{"created_by":5,"id":"583","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"583"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000583","sets":["74","74:26"]},"author_link":["3494","2814","3491","3489","1430","3490"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"474","bibliographicPageStart":"467","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Journal of Nutritional Science and Vitaminology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of a threonine-imbalanced diet （8% casein supplemented with 0.3% methionine, TI） on the ketone body production and the secretion rate of lipids were examined in the isolated perfused rat liver. Feeding a TI diet compared to an 8% casein （C） diet resulted in an enlargement of liver, presumably due to 2-4-fold accumulation of triglyceride. Serum triglyceride likewise increased significantly in rats fed a TI diet. No significant difference was found in the other lipid components both in serum and liver. When the livers from rats fed C or TI diets were isolated and perfused in the presence of an exogenous oleate substrate, the TI diet decreased the ketone body production and conversely increased the secretion rate of triglyceride, suggesting an inverse relationship between rates of ketogenesis and triglyceride secretion. The proportion of oleate in the perfusate triglyceride obtained at the end of perfusion was comparable between the C and TI groups, whereas in the post-perfused liver it was higher in the former than in the latter, suggesting a stimulatory effect of the TI diet on the secretion of the oleate in the form of triglyceride. These results indicate that altered hepatic metabolism of long-chain free fatty acids between the pathways of oxidation and esterification is one of the causative factors for triglyceride accumulation in the liver produced by threonine imbalance.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Vitamin Society of Japan","subitem_publisher_language":"en"},{"subitem_publisher":"日本ビタミン学会","subitem_publisher_language":"ja"}]},"item_10001_relation_18":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.3177/jnsv.36.467"}]}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本ビタミン学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal@rchiveから複製したものである","subitem_rights_language":"ja"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00703822","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03014800","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 亘博","creatorNameLang":"ja"},{"creatorName":"フクダ, ノブヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukuda, Nobuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"日高, 敏郎","creatorNameLang":"ja"},{"creatorName":"ヒダカ, トシロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"戸田, 隆義","creatorNameLang":"ja"},{"creatorName":"トダ, タカヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"菅野, 道廣","creatorNameLang":"ja"},{"creatorName":"スガノ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugano, Michihiro","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hidaka, Toshiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toda, Takayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"菅野, 道廣","creatorNameLang":"ja"},{"creatorName":"スガノ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugano, Michihiro","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"FN_880.pdf","filesize":[{"value":"805.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"FN_880.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/583/files/FN_880.pdf"},"version_id":"b873254e-6c32-4f34-8b38-21f3eb488edf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Threonine imbalance, Fatty acid metabolism, Ketone body production, Triglyceride secretion, Liver perfusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-02"},"publish_date":"2011-12-02","publish_status":"0","recid":"583","relation_version_is_last":true,"title":["Altered hepatic metabolism of free fatty acid in rats fed a threonine-imbalanced diet"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-09-25T04:42:36.328825+00:00"}