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Dietary 5-Campestenone (Campest-5-en-3-one) Enhances Fatty Acid Oxidation in Perfused Rat Liver
http://hdl.handle.net/10458/3524
http://hdl.handle.net/10458/3524e8dffddd-bcf2-4d08-b8ef-445adca04f6d
| 名前 / ファイル | ライセンス | アクション |
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fukuda6_J.Nutr.Sci.Vitaminol_vol.52-2_2006.cinii.pdf (868.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-11-29 | |||||
| タイトル | ||||||
| タイトル | Dietary 5-Campestenone (Campest-5-en-3-one) Enhances Fatty Acid Oxidation in Perfused Rat Liver | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | 5-campestenone, perfused rat liver, ketone body production, triacylglycerol (TG) secretion | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
田丸, 靜香
× 田丸, 靜香× Suzuki, Yo× 窄野, 昌信× Fukuda, Nobuhiro× Ikeda, Ikuo× Konno, Rie× Shimizu, Takeshi× Suzuki, Kunio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of dietary 5-campestenone （campest-5-en-3-one）, a chemical modification product of a naturally-occurring plant sterol, campesterol, on lipid metabolism was examined using a rat liver perfusion system. Male Sprague-Dawley rats weighing about 140g were fed a diet supplemented with or without 0.2% 5-campestenone for 14 d. 5-Campestenone feeding resulted in a marked reduction in the concentrations of serum lipids, such as triacylglycerol （TG）, cholesterol, phospholipid, and free fatty acid, without influencing food intake or growth. Then, isolated livers from both groups were perfused for 4h in the presence of an exogenous linoelaidic acid substrate. Dietary 5-campestenone markedly elevated hepatic ketone body production, while cumulative secretions of TG, cholesterol, and phospholipid by the livers of rats fed 5-campestenone were all significantly lowered as compared to those fed without the compound; the extent of the reduction was more prominent in the secretion of TG than other lipid components. In addition, the reduction of TG secretion was concomitantly accompanied by the reduced incorporation of both exogenous and endogenous fatty acids into this lipid molecule. These results suggest that dietary 5-campestenone exerts its hypotriglyceridemic effect, at least, in part through an enhanced metabolism of endogenous and exogenous fatty acids to oxidation at the expense of esterification in rat liver. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Journal of Nutritional Science and Vitaminology 巻 52, 号 2, p. 127-133, 発行日 2006-04 |
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| 出版者 | ||||||
| 出版者 | The Vitamin Society of Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 03014800 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 16802693 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 日本ビタミン学会 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://ci.nii.ac.jp/naid/110004718471 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
