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  1. 農学部
  2. 学術雑誌掲載論文 (農学部)

Development of basophils in mongolian gerbils: Formation of basophilic cell clusters in the bone marrow after Nippostrongylus brasiliensis infection

http://hdl.handle.net/10458/1923
http://hdl.handle.net/10458/1923
c998d719-508d-44d5-bcaa-4f2fd839d48d
名前 / ファイル ライセンス アクション
li76-1.pdf li76-1.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2009-03-02
タイトル
タイトル Development of basophils in mongolian gerbils: Formation of basophilic cell clusters in the bone marrow after Nippostrongylus brasiliensis infection
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
キーワード basophil, mast cell, peroxidase, bone marrow, Monogolian gerbil, ultrastructure, Nippostrongylus brasiliensis
資源タイプ
資源タイプ journal article
著者 Okada, Manabu

× Okada, Manabu

WEKO 3335

en Okada, Manabu

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Nawa, Yukifumi

× Nawa, Yukifumi

WEKO 3336

en Nawa, Yukifumi

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Horii, Yoichiro

× Horii, Yoichiro

WEKO 1667

en Horii, Yoichiro

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Kitamura, Tadashi

× Kitamura, Tadashi

WEKO 3338

en Kitamura, Tadashi

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Arizono, Naoki

× Arizono, Naoki

WEKO 3339

en Arizono, Naoki

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抄録
内容記述タイプ Abstract
内容記述 Development of basophilic leukocytes was studied in the Mongolian gerbil, Meriones unguiculatus, after infection with the nematode Nippostrongylus brasiliensis. After infection, peripheral blood basophilia developed and peaked at 2 weeks. In bone marrow sections, numbers of alcian blue+/safranine basophilic cells were increased. These cells did not bind berberine sulfate and were clearly distinguishable from the bone marrow- resident mast cells, safranine+ and berberine sulfate+. Alcian blue+/safranine cells were identified by electron microscopy as basophilic myelocytes in various stages of maturation. In the early period of infection, these cells had round-to-oval granules with a homogenous electron-dense matrix, a well-developed Golgi apparatus and rough endoplasmic reticulum, and a nonsegmented nucleus. By enzyme cytochemical analysis, intense peroxidase activity was demonstrated in all of the specific granules as well as in the rough endoplasmic reticulum and Golgi apparatus. Two weeks after infection, the number of bone marrow basophilic cells further increased, forming distinct clusters or islands composed of up to 100 cells each. On electron micrographs, the basophilic cells in these clusters appeared to be late- stage basophilic myelocytes, ie, having an increased number of granules, a less-conspicuous Golgi apparatus and rough endoplasmic reticulum, a horseshoe-shaped-to-lobulated nucleus, and reduced peroxidase activity. Eosinophils and mast cells were rarely found in the basophilic cell clusters. Four weeks after infection, the clusters had disappeared. These results show that gerbil basophilic myelocytes tend to form cell clusters in the bone marrow during their active proliferation. The comparative paucity of other cell lineages in basophilic cell clusters suggests that basophilia is generated from differentiation/proliferation of precommitted basophil progenitors independently from cells of other lineages.
言語 en
書誌情報 en : Laboratory investigation : journal of technical methods and pathology

巻 76, 号 1, p. 89-97, 発行日 1997-01
出版者
出版者 Nature Publishing Group
言語 en
ISSN
収録物識別子タイプ ISSN
収録物識別子 00236837
ISSN
収録物識別子タイプ ISSN
収録物識別子 15300307
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00713961
著者版フラグ
出版タイプ AM
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Cite as

Okada, Manabu, Nawa, Yukifumi, Horii, Yoichiro, Kitamura, Tadashi, Arizono, Naoki, 1997, Development of basophils in mongolian gerbils: Formation of basophilic cell clusters in the bone marrow after Nippostrongylus brasiliensis infection: Nature Publishing Group, 89–97 p.

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