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ROS mediated FOXO transcription factors pathway inhibition is the keyevent during Arsenic acid induced cellular senescence in fibroblast cell
http://hdl.handle.net/10458/6280
http://hdl.handle.net/10458/628095850d12-7f67-4067-a9f1-5cfe084f1bcf
| 名前 / ファイル | ライセンス | アクション |
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本文 (157.8 kB)
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| Item type | その他 / Others(1) | |||||||||||||||||||||||
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| 公開日 | 2020-06-21 | |||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||
| タイトル | ROS mediated FOXO transcription factors pathway inhibition is the keyevent during Arsenic acid induced cellular senescence in fibroblast cell | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||||
| 主題 | Arsenic acid, Oxidative stress, mammalian Ste20-like protein kinase, Forkhead box O transcription factors, cellular senescenc | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||||||||||||||||||||
| 資源タイプ | other | |||||||||||||||||||||||
| 著者 |
山口, 優也
× 山口, 優也× マドゥエスタ, ハリーシャクマール
WEKO
7810
× Madhyastha, Radha× チヨウジヨウフ, ナランツオツク
WEKO
26967
× 菱川, 善隆
WEKO
34189
× Yutthana, Pengjam× Nakajima, Yuichi× 丸山, 眞杉 |
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Arsenic exposure through drinking water is a major public health problem. It causes a number of toxic effects on skin. Arsenic has been reported to inhibit cancer cell migration and proliferation. However, re ports about the molecular effects of arsenic acid on normal skin fibroblast cells are limited. Here, we investigated the molecular effect on arsenic acidmediated inhibition of cell migration using mouse skin fibroblast cell line （m5S）. The present study found that 10 ppm arsenic acid inhibits cell migration, although it had no effect on cell death at this dose. Arsenic acid induced the generation of reactive oxygen species （ROS）, resulting in oxidative stress to DNA. It also activated the mammalian Ste20-like protein kinase 1 （MSTl）; however the serine/threonine kinase Akt was downregulated. Forkhead box O （FOXO） transcription factors are activated by MSTl under stress conditions. They are inhibited by phosphorylation by Akt through external and internal stimuli. Activation of FOXOs assist in their nuclear localization and increased transcriptional activity. Our results showed that arsenic induced the nuclear translocation of FOXO1 and FOXO3a. Their target genes were regulated to accumulate the cell cycle in the G2/M phase. These effects caused cellular senescence. Taken together, our results indicate that arsenic acid inhibited cell migration through cellular senescence process regulated by MST1-FOXO signaling pathway. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| 書誌情報 |
en : 4th InternationalArsenic Symposium in MIYAZAKI 2015 p. 94-95, 発行日 2015-10 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | University of Miyazaki, IRISH | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
