{"created":"2023-05-15T10:01:04.371548+00:00","id":5568,"links":{},"metadata":{"_buckets":{"deposit":"5674823c-99be-45b3-86f1-b3f049fda15a"},"_deposit":{"created_by":5,"id":"5568","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"5568"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00005568","sets":["80","80:65"]},"author_link":["26963","26967","2630","7810","29990","34189","29986","29989"],"item_10010_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"95","bibliographicPageStart":"94","bibliographic_titles":[{"bibliographic_title":"4th InternationalArsenic Symposium in MIYAZAKI 2015","bibliographic_titleLang":"en"}]}]},"item_10010_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Arsenic exposure through drinking water is a major public health problem. It causes a number of toxic effects on skin. Arsenic has been reported to inhibit cancer cell migration and proliferation. However, re ports about the molecular effects of arsenic acid on normal skin fibroblast cells are limited. Here, we investigated the molecular effect on arsenic acidmediated inhibition of cell migration using mouse skin fibroblast cell line （m5S）. The present study found that 10 ppm arsenic acid inhibits cell migration, although it had no effect on cell death at this dose. Arsenic acid induced the generation of reactive oxygen species （ROS）, resulting in oxidative stress to DNA. It also activated the mammalian Ste20-like protein kinase 1 （MSTl）; however the serine/threonine kinase Akt was downregulated. Forkhead box O （FOXO） transcription factors are activated by MSTl under stress conditions. They are inhibited by phosphorylation by Akt through external and internal stimuli. Activation of FOXOs assist in their nuclear localization and increased transcriptional activity. Our results showed that arsenic induced the nuclear translocation of FOXO1 and FOXO3a. Their target genes were regulated to accumulate the cell cycle in the G2/M phase. These effects caused cellular senescence. Taken together, our results indicate that arsenic acid inhibited cell migration through cellular senescence process regulated by MST1-FOXO signaling pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10010_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"University of Miyazaki, IRISH","subitem_publisher_language":"en"}]},"item_10010_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山口, 優也","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, ユウヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamaguchi, Yuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"山口","familyNameLang":"ja"},{"familyName":"ヤマグチ","familyNameLang":"ja-Kana"},{"familyName":"Yamaguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"優也","givenNameLang":"ja"},{"givenName":"ユウヤ","givenNameLang":"ja-Kana"},{"givenName":"Yuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"26963","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"Madhyastha, Harishkumar","creatorNameLang":"en"},{"creatorName":"マドゥエスタ, ハリーシャクマール","creatorNameLang":"ja"},{"creatorName":"マドゥエスタ, ハリーシャクマール","creatorNameLang":"ja-Kana"},{"creatorName":"Madhyastha, Harish Kumar","creatorNameLang":"en"}],"familyNames":[{"familyName":"Madhyastha","familyNameLang":"en"},{"familyName":"マドゥエスタ","familyNameLang":"ja"},{"familyName":"マドゥエスタ","familyNameLang":"ja-Kana"},{"familyName":"Madhyastha","familyNameLang":"en"}],"givenNames":[{"givenName":"Harishkumar","givenNameLang":"en"},{"givenName":"ハリーシャクマール","givenNameLang":"ja"},{"givenName":"ハリーシャクマール","givenNameLang":"ja-Kana"},{"givenName":"Harish Kumar","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Madhyastha, 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ナランツオツク","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Choijookhuu","familyNameLang":"en"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja"},{"familyName":"チヨウジヨウフ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Narantsog","givenNameLang":"en"},{"givenName":"ナランツオツク","givenNameLang":"ja"},{"givenName":"ナランツオツク","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"26967","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90640962","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90640962"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"菱川, 善隆","creatorNameLang":"ja"},{"creatorName":"ヒシカワ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hishikawa, Yoshitaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"菱川","familyNameLang":"ja"},{"familyName":"ヒシカワ","familyNameLang":"ja-Kana"},{"familyName":"Hishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"善隆","givenNameLang":"ja"},{"givenName":"ヨシタカ","givenNameLang":"ja-Kana"},{"givenName":"Yoshitaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34189","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60304276","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60304276"}]},{"creatorNames":[{"creatorName":"Yutthana, Pengjam","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"29989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, 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マスギ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Maruyama","familyNameLang":"en"},{"familyName":"丸山","familyNameLang":"ja"},{"familyName":"マルヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Masugi","givenNameLang":"en"},{"givenName":"眞杉","givenNameLang":"ja"},{"givenName":"マスギ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2630","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"p6_arsenic2015.pdf","filesize":[{"value":"157.8 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