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The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese
http://hdl.handle.net/10458/5464
http://hdl.handle.net/10458/5464037d47c5-4264-4504-9772-2fb7edbd419e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-21 | |||||
| タイトル | ||||||
| タイトル | The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Immune escape, TAP1, Genetic polymorphism, Colorectal cancer, Japanese | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
山内, 武紀
× 山内, 武紀× 竹内, 昌平× 前原, 直樹× 黒田, 嘉紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Although colorectal cancer （CRC） is one of the most frequent malignancies in Japan, the associated genetic factors remain to be elucidated. Functional loss of the transporter associated with antigen processing （TAP） 1 gene induces carcinogenesis. We investigated whether single nucleotide polymorphisms （SNPs） in the TAP1 gene （rs735883） are associated with susceptibility to CRC in a Japanese population. Methods: The study participants were 143 cases and 243 clinical controls. After extracting DNA from their peripheral blood cells, genotyping was conducted by the polymerase chain reaction–restriction fragment length polymorphism method. Results: Participants with a mutated allele had an increased risk for CRC. The adjusted odds ratios for the C/T, T/T, and the mutation type （C/T + T/T） compared to that of wild type （C/C） were 2.27 [95 % confidence interval （CI）, 1.43–3.67], 1.95 （95 % CI, 0.88–4.30）, and 2.22 （95 % CI, 1.42–3.55）, respectively. Furthermore, a significant trend in the rate of cases was observed with an increasing number of mutated alleles （P for trend = 0.0068）. Conclusions: The genotype of the TAP1 gene is associated with susceptibility to CRC. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 本論文に関連する研究論文 Yamauchi T, Takeuchi S, Maehara N, Kuroda Y. The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese. Environ Health Prev Med. 2014 Jul;19(4):265-70. doi: 10.1007/s12199-014-0388-4. Epub 2014 May 7. PMID: 24803408; PMCID: PMC4085250. |
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| 言語 | ja | |||||
| 書誌情報 |
en : Environmental Health and Preventive Medicine 巻 19, 号 4, p. 265-270, 発行日 2014-07 |
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| 出版者 | ||||||
| 出版者 | Springer Japan | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Japanese Society for Hygiene | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13474715 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s12199-014-0388-4 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | NA | |||||
