{"created":"2023-05-15T10:00:17.937673+00:00","id":4615,"links":{},"metadata":{"_buckets":{"deposit":"6243a0e7-7e6c-46ca-ab6f-fd8375c883c7"},"_deposit":{"created_by":5,"id":"4615","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"4615"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00004615","sets":["76","76:64"]},"author_link":["22785","22917","24852","22781"],"control_number":"4615","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"270","bibliographicPageStart":"265","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Environmental Health and Preventive Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: Although colorectal cancer （CRC） is one of the most frequent malignancies in Japan, the associated genetic factors remain to be elucidated. Functional loss of the transporter associated with antigen processing （TAP） 1 gene induces carcinogenesis. We investigated whether single nucleotide polymorphisms （SNPs） in the TAP1 gene （rs735883） are associated with susceptibility to CRC in a Japanese population. \nMethods: The study participants were 143 cases and 243 clinical controls. After extracting DNA from their peripheral blood cells, genotyping was conducted by the polymerase chain reaction–restriction fragment length polymorphism method. \nResults: Participants with a mutated allele had an increased risk for CRC. The adjusted odds ratios for the C/T, T/T, and the mutation type （C/T + T/T） compared to that of wild type （C/C） were 2.27 [95 % confidence interval （CI）, 1.43–3.67], 1.95 （95 % CI, 0.88–4.30）, and 2.22 （95 % CI, 1.42–3.55）, respectively. Furthermore, a significant trend in the rate of cases was observed with an increasing number of mutated alleles （P for trend = 0.0068）. \nConclusions: The genotype of the TAP1 gene is associated with susceptibility to CRC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本論文に関連する研究論文\nYamauchi T, Takeuchi S, Maehara N, Kuroda Y. The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese. Environ Health Prev Med. 2014 Jul;19(4):265-70. doi: 10.1007/s12199-014-0388-4. Epub 2014 May 7. PMID: 24803408; PMCID: PMC4085250.","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Society for Hygiene","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12199-014-0388-4","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474715","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Yamauchi, Takenori","creatorNameLang":"en"},{"creatorName":"山内, 武紀","creatorNameLang":"ja"},{"creatorName":"ヤマウチ, タケノリ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹内, 昌平","creatorNameLang":"ja"},{"creatorName":"タケウチ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Shouhei","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前原, 直樹","creatorNameLang":"ja"},{"creatorName":"マエハラ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Maehara, Naoki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Kuroda, Yoshiki","creatorNameLang":"en"},{"creatorName":"黒田, 嘉紀","creatorNameLang":"ja"},{"creatorName":"クロダ, ヨシキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Immune escape, TAP1, Genetic polymorphism, Colorectal cancer, Japanese","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-06-21"},"publish_date":"2020-06-21","publish_status":"0","recid":"4615","relation_version_is_last":true,"title":["The genotype of the transporter associated with antigen processing gene affects susceptibility to colorectal cancer in Japanese"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2024-01-29T04:56:25.953010+00:00"}