WEKO3
アイテム
Aberrant expression of monocarboxylate transporter 4 in tumour cells predicts an unfavourable outcome in patients with hepatocellular carcinoma
http://hdl.handle.net/10458/5036
http://hdl.handle.net/10458/5036813c49fb-f16d-439f-847e-be901cf2bf26
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||
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| 公開日 | 2020-06-21 | |||||||||||||||||||||||
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| タイトル | Aberrant expression of monocarboxylate transporter 4 in tumour cells predicts an unfavourable outcome in patients with hepatocellular carcinoma | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||
| キーワード | ||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
| キーワード | hepatocellular carcinoma, MCT4, prognosis, tumour-associated macrophages | |||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||
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| アクセス権 | metadata only access | |||||||||||||||||||||||
| 著者 |
大野, 招伸
× 大野, 招伸× 頼田, 顕辞× 春山, 幸洋× 近藤, 千博
WEKO
7975
× 加藤, 淳彦× 大友, 俊彥× 川口, 真紀子
WEKO
9881
× 丸塚, 浩助× 千々岩, 一男× 片岡, 寛章
WEKO
9886
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| 抄録 | ||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||
| 内容記述 | Background & Aims: The tumour cell microenvironment, which includes local oxygen saturation, pericellular pH and stromal cells, can modulate tumour progression. This study determined the prognostic impact of infiltrating tumour-associated macrophages and the expression of monocarboxylate transporter 4 （MCT4） and glypican 3 （GPC3） in hepatocellular carcinoma （HCC） clinical specimens. Methods: A total of 225 cases of resected HCC were subjected to immunohistochemical analyses of CD68, CD204, MCT4 and GPC3. Immunoreactivities and other common clinicopathological parameters were subjected to univariate prognostic analyses for overall survival （OS, n = 225） and disease-free survival （DFS, n = 222）. All variables with prognostic impact were further analysed in multivariate analysis. Results: Increased intratumoural infiltration of CD204-positive or MCT4-positive macrophages suggested shorter OS （P = 0.015 or P = 0.001 respectively）, but DFS was not altered. The GPC3 score （with an emphasis on circumferential immunoreactivity） was correlated with shorter OS and DFS. Aberrant expression of MCT4 in HCC cells was observed in a subset of HCC cases （21%, 47/225）. In those cases, significantly poorer OS （P < 0.0001） and DFS （P = 0.0003） were observed, and there was a positive correlation with the intratumoural infiltration of CD204- or MCT4-positive macrophages and the GPC3 score. Multivariate analysis showed that aberrant MCT4 expression in HCC cells was an independent prognostic factor for shorter OS （P = 0.018） and DFS （P = 0.006） after resection of HCC. Conclusion: Aberrant expression of MCT4 in carcinoma cells serves as a novel, independent prognostic factor for HCC, indicating a poorer patient outcome. | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||||||||
| 内容記述 | Citation: Nomura I, Kato J, Tokashiki M, Kitamura K. Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. Regul Pept. 2009 Nov 27;158(1-3):127-31. doi: 10.1016/j.regpep.2009.08.003. Epub 2009 Aug 23. PMID: 19706311. |
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| 言語 | en | |||||||||||||||||||||||
| 書誌情報 |
en : Liver International 巻 34, 号 6, p. 942-952, 発行日 2014-07 |
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| 出版者 | ||||||||||||||||||||||||
| 出版者 | John Wiley & Sons A/S | |||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||
| 収録物識別子 | 14783231 | |||||||||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.regpep.2009.08.003 | |||||||||||||||||||||||
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| 出版タイプ | NA | |||||||||||||||||||||||
