@article{oai:miyazaki-u.repo.nii.ac.jp:00004176,
 author = {大野, 招伸 and Ohno, Akinobu and 頼田, 顕辞 and Yorita, Kenji and 春山, 幸洋 and Haruyama, Yukihiro and Kondo, Kazuhiro and 近藤, 千博 and 加藤, 淳彦 and Kato, Atsuhiko and 大友, 俊彥 and Ohtomo, Toshihiko and Kawaguchi, Makiko and 川口, 真紀子 and 丸塚, 浩助 and Marutsuka, Kousuke and 千々岩, 一男 and Chijiiwa, Kazuo and Kataoka, Hiroaki and 片岡, 寛章},
 issue = {6},
 journal = {Liver International},
 month = {Jul},
 note = {Background & Aims: The tumour cell microenvironment, which includes local oxygen saturation, pericellular pH and stromal cells, can modulate tumour progression. This study determined the prognostic impact of infiltrating tumour-associated macrophages and the expression of monocarboxylate transporter 4 （MCT4） and glypican 3 （GPC3） in hepatocellular carcinoma （HCC） clinical specimens. Methods: A total of 225 cases of resected HCC were subjected to immunohistochemical analyses of CD68, CD204, MCT4 and GPC3. Immunoreactivities and other common clinicopathological parameters were subjected to univariate prognostic analyses for overall survival （OS, n = 225） and disease-free survival （DFS, n = 222）. All variables with prognostic impact were further analysed in multivariate analysis. Results: Increased intratumoural infiltration of CD204-positive or MCT4-positive macrophages suggested shorter OS （P = 0.015 or P = 0.001 respectively）, but DFS was not altered. The GPC3 score （with an emphasis on circumferential immunoreactivity） was correlated with shorter OS and DFS. Aberrant expression of MCT4 in HCC cells was observed in a subset of HCC cases （21%, 47/225）. In those cases, significantly poorer OS （P < 0.0001） and DFS （P = 0.0003） were observed, and there was a positive correlation with the intratumoural infiltration of CD204- or MCT4-positive macrophages and the GPC3 score. Multivariate analysis showed that aberrant MCT4 expression in HCC cells was an independent prognostic factor for shorter OS （P = 0.018） and DFS （P = 0.006） after resection of HCC. Conclusion: Aberrant expression of MCT4 in carcinoma cells serves as a novel, independent prognostic factor for HCC, indicating a poorer patient outcome., Citation:
Nomura I, Kato J, Tokashiki M, Kitamura K. Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity. Regul Pept. 2009 Nov 27;158(1-3):127-31. doi: 10.1016/j.regpep.2009.08.003. Epub 2009 Aug 23. PMID: 19706311.},
 pages = {942--952},
 title = {Aberrant expression of monocarboxylate transporter 4 in tumour cells predicts an unfavourable outcome in patients with hepatocellular carcinoma},
 volume = {34},
 year = {2014},
 yomi = {オオノ, アキノブ and ヨリタ, ケンジ and ハルヤマ, ユキヒロ and コンドウ, カズヒロ and カトウ, アツヒコ and オオトモ, トシヒコ and カワグチ, マキコ and マルツカ, コウスケ and チヂイワ, カズオ and カタオカ, ヒロアキ}
}