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  1. 農学部
  2. 学術雑誌掲載論文 (農学部)

Differential expression patterns of Wnt and β-catenin/TCF Target genes in the uterus of immature female rats exposed to 17α-ethynyl estradiol

http://hdl.handle.net/10458/726
http://hdl.handle.net/10458/726
0124c55f-665e-4692-bf12-7cc0fc9bb13d
名前 / ファイル ライセンス アクション
ashizawa82.pdf ashizawa82.pdf (2.4 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-10-10
タイトル
タイトル Differential expression patterns of Wnt and β-catenin/TCF Target genes in the uterus of immature female rats exposed to 17α-ethynyl estradiol
言語 en
タイトル
タイトル Downregulation of Wnt7a mRNA by EE
言語 en
言語
言語 eng
キーワード
言語 ja
主題Scheme Other
キーワード 精子
キーワード
言語 en
主題Scheme Other
キーワード sperm, Estrogen receptor agonist, Uterus, Wnt genes, β-catenin/TCF-target genes
資源タイプ
資源タイプ journal article
著者 芦沢, 幸二

× 芦沢, 幸二

WEKO 932

ja 芦沢, 幸二

en Ashizawa, Koji

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Katayama, Seiichi

× Katayama, Seiichi

WEKO 2212

en Katayama, Seiichi

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Fukuhara, Tadahiro

× Fukuhara, Tadahiro

WEKO 2214

en Fukuhara, Tadahiro

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Hiroyasu, Makoto

× Hiroyasu, Makoto

WEKO 2215

en Hiroyasu, Makoto

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Tsuzuki, Yasuhiro

× Tsuzuki, Yasuhiro

WEKO 2104
e-Rad 00236928

en Tsuzuki, Yasuhiro

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Tatemoto, Hideki

× Tatemoto, Hideki

WEKO 2217

en Tatemoto, Hideki

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Nakada, Tadashi

× Nakada, Tadashi

WEKO 2218

en Nakada, Tadashi

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Nagai, Kenji

× Nagai, Kenji

WEKO 2219

en Nagai, Kenji

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抄録
内容記述タイプ Abstract
内容記述 To characterize the effects of an estrogen receptor (ER) agonist on the gene expressions in the uterus, immature female rats were administered once orally with 17α-ethynyl estradiol (EE, 3 μg/kg), a potent ER agonist. We focused on 4 categories of sex steroid hormone receptor genes: well-known estrogen target genes; Wnt genes; and β-catenin/TCF target genes. The mRNA expression levels of ERα, ERβ, progesterone receptor, and androgen receptor were all downregulated at 24 and/or 48 h after EE administration. Although the time courses of Wnt4, Wnt5a, and Wnt7a mRNA status varied until 12 h after EE administration, all of them were simultaneously downregulated at 24 and 48 h. The gene showing the highest transcriptional response to EE was Wnt7a mRNA. Therefore, Wnt7a mRNA is considered to be the major locus of action for estrogenic compounds in the immature uterus. In the β-catenin/TCF target genes, the downregulation of anti-Mullerian hormone type 2 receptor (Amhr2) and bone morphogenetic protein 4 (Bmp4) mRNA after EE administration appeared to be closely related to the downregulation of Wnt7a. The upregulation of cyclin D1 and follistatin mRNA at the early phase after EE administration was considered to have been affected by the upregulation of Wnt4. These results indicate that an ER agonist influences not only the mRNA expression of sex steroid hormone receptor genes and well-known estrogen target genes, but also Wnt genes (Wnt4, Wnt5a, Wnt7a) and β-catenin/TCF target genes in the uterus of immature rats, indicating that their molecules are the potential players affected by estrogenic stimuli.
言語 en
書誌情報 en : Toxicological sciences : an official journal of the Society of Toxicology

巻 91, 号 2, p. 419-430, 発行日 2006
ISSN
収録物識別子タイプ ISSN
収録物識別子 10966080
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA11221142
著者版フラグ
出版タイプ AM
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