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Differential expression patterns of Wnt and β-catenin/TCF Target genes in the uterus of immature female rats exposed to 17α-ethynyl estradiol
http://hdl.handle.net/10458/726
http://hdl.handle.net/10458/7268eae9a45-7a90-4c8e-9c61-11faa8d30e7b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ashizawa82.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2007-10-10 | |||||
| タイトル | ||||||
| タイトル | Differential expression patterns of Wnt and β-catenin/TCF Target genes in the uterus of immature female rats exposed to 17α-ethynyl estradiol | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | ja | |||||
| 主題Scheme | Other | |||||
| キーワード | 精子 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | sperm, Estrogen receptor agonist, Uterus, Wnt genes, β-catenin/TCF-target genes | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| その他（別言語等）のタイトル | ||||||
| その他のタイトル | Downregulation of Wnt7a mRNA by EE | |||||
| 言語 | en | |||||
| 著者 |
芦沢, 幸二
× 芦沢, 幸二× Katayama, Seiichi× Fukuhara, Tadahiro× Hiroyasu, Makoto× 續木, 靖浩× 建本, 秀樹× Nakada, Tadashi× Nagai, Kenji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To characterize the effects of an estrogen receptor (ER) agonist on the gene expressions in the uterus, immature female rats were administered once orally with 17α-ethynyl estradiol (EE, 3 μg/kg), a potent ER agonist. We focused on 4 categories of sex steroid hormone receptor genes: well-known estrogen target genes; Wnt genes; and β-catenin/TCF target genes. The mRNA expression levels of ERα, ERβ, progesterone receptor, and androgen receptor were all downregulated at 24 and/or 48 h after EE administration. Although the time courses of Wnt4, Wnt5a, and Wnt7a mRNA status varied until 12 h after EE administration, all of them were simultaneously downregulated at 24 and 48 h. The gene showing the highest transcriptional response to EE was Wnt7a mRNA. Therefore, Wnt7a mRNA is considered to be the major locus of action for estrogenic compounds in the immature uterus. In the β-catenin/TCF target genes, the downregulation of anti-Mullerian hormone type 2 receptor (Amhr2) and bone morphogenetic protein 4 (Bmp4) mRNA after EE administration appeared to be closely related to the downregulation of Wnt7a. The upregulation of cyclin D1 and follistatin mRNA at the early phase after EE administration was considered to have been affected by the upregulation of Wnt4. These results indicate that an ER agonist influences not only the mRNA expression of sex steroid hormone receptor genes and well-known estrogen target genes, but also Wnt genes (Wnt4, Wnt5a, Wnt7a) and β-catenin/TCF target genes in the uterus of immature rats, indicating that their molecules are the potential players affected by estrogenic stimuli. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Toxicological sciences : an official journal of the Society of Toxicology 巻 91, 号 2, p. 419-430, 発行日 2006 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 10966080 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11221142 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
