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言語習得後失聴者における一次聴覚野でのグルコース代謝 : FDG-PETによる評価
http://hdl.handle.net/10458/4876
http://hdl.handle.net/10458/487646e22cd2-4fe7-436b-a005-eaa26670cb61
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論文要旨 (106.7 kB)
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学位論文審査結果の要旨 (69.9 kB)
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博士学位論文 (6.0 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2014-06-09 | |||||
| タイトル | ||||||
| タイトル | Glucose metabolism in primary auditory cortex of postlingually deaf patients : FDG-PET study | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 言語習得後失聴者における一次聴覚野でのグルコース代謝 : FDG-PETによる評価 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | FDG-PET, neuroplasticity, auditory cortex, deafness | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
奥田, 匠
× 奥田, 匠 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | [Background/Purpose] Previous FDG-PET studies have indicated neuroplasticity in the adult auditory cortex in cases of postlingual deafness. In the mature brain, auditory deprivation decreased neuronal activity in primary auditory and auditory-related cortices. In order to reevaluate these issues, we used statistical analytic software, three-dimensional stereotaxic region of interest (ROI) template (3DSRT), in addition to statistical parametric mapping (SPM). [Materials and Methods] 18F-FDG brain PET scans were performed on 7 postlingually deaf patients and 10 healthy volunteers. Significant increases and decreases of regional cerebral glucose metabolism in the patient group were estimated by comparing their PET images with those of the healthy volunteers using SPM analysis and 3DSRT. [Results] The glucose metabolism of deaf patients was found to be lower than that of the control subjects in the right superior temporal gyrus, both middle temporal gyri, left inferior temporal gyrus, right lobule parietalis inferior, and left insular cortex by SPM. 3DSRT data also revealed significantly decreased glucose metabolism in both primary auditory cortices in postlingually deaf patients. [Conclusion] SPM and 3DSRT analyses indicated that glucose metabolism decreases in the primary auditory cortex of postlingually deaf patients. The previous results of PET studies were confirmed. Our method involving 3DSRT is useful. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| ja | ||||||
| 本論文に関連する研究論文 Okuda T, Nagamachi S, Ushisako Y, Tono T. Glucose metabolism in the primary auditory cortex of postlingually deaf patients: an FDG-PET study. ORL J Otorhinolaryngol Relat Spec. 2013;75(6):342-9. doi: 10.1159/000357474. Epub 2014 Jan 10. PMID: 24435067. |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17601 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 宮崎大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2013年度 | |||||
| 言語 | ja | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2014-03-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 医博乙第50号 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| リンク |
Glucose Metabolism in the Primary Auditory Cortex of Postlingually Deaf Patients: An FDG-PET Study
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