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動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析
http://hdl.handle.net/10458/4966
http://hdl.handle.net/10458/4966d5d99518-752d-46bb-aacb-797e26e7d22e
| 名前 / ファイル | ライセンス | アクション |
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論文要旨 (58.9 kB)
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学位論文審査結果の要旨 (58.2 kB)
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博士学位論文 (723.7 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2014-09-03 | |||||
| タイトル | ||||||
| タイトル | The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Plaque erosion, Animal model, Computational fluid dynamics | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
鮫島, 直樹
× 鮫島, 直樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aim: To clarify the contribution of hemodynamic factors to the onset of plaque erosion in smooth muscle cell (SMC)-rich atherosclerotic plaque. Methods: We developed a rabbit model of SMC-rich atherosclerotic plaque with various degree of stenosis induced by incomplete ligation and generated three-dimensional models of five rabbit femoral arteries based on 130-162 serial histological cross-sections at 100-μm intervals per artery. We performed a computational blood flow simulation using the Reynolds-averaged Navier-Stokes model and calculated the wall shear stress (WSS), turbulence kinetic energy (TKE), blood pressure (BP) and blood pressure gradients (BPG) in eight sections (the inlet, the stenotic portion and areas 1, 2 and 5mm from the stenotic portion) in each rabbit. We also investigated whether the magnitude of WSS or TKE was related to the presence or absence of erosive injury by evaluating six points (the locally highest, median and lowest of WSS or TKE) in each section. Results: The magnitudes of WSS, TKE and BPG, but not BP, correlated significantly with the extent of histologically-defined plaque erosion (WSS, r=0.55, p<0.001; TKE, r=0.53, p<0.001; BPG, r=0.61, p<0.0001, n=40). The values for WSS and TKE were significantly larger at sites with, compared to without, erosive injury (n=107 and n=119 points, respectively; both p<0.0001). Conclusions: These results suggest that increased values of WSS, TKE and BPG considerably contribute to the onset of plaque erosion. |
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| 言語 | en | |||||
| 内容記述 | ||||||
| ja | ||||||
| 本論文に関連する研究論文 Sameshima N, Yamashita A, Sato S, Matsuda S, Matsuura Y, Asada Y. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits. J Atheroscler Thromb. 2014;21(8):831-8. doi: 10.5551/jat.23093. Epub 2014 Mar 25. PMID: 24671111. |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17601 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 宮崎大学 | |||||
| 学位授与年度 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2014年度 | |||||
| 言語 | ja | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2014-05-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 医博甲第420号 | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://hdl.handle.net/10458/4967 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| リンク |
The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits
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