{"created":"2023-05-15T09:59:40.401797+00:00","id":3869,"links":{},"metadata":{"_buckets":{"deposit":"46367c2e-02af-4de8-a366-780df74058f4"},"_deposit":{"created_by":9,"id":"3869","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"3869"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00003869","sets":["72","72:54"]},"author_link":["9694"],"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-05-23"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"宮崎大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17601","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_10006_description_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_description":"2014年度","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: To clarify the contribution of hemodynamic factors to the onset of plaque erosion in smooth muscle cell (SMC)-rich atherosclerotic plaque.\nMethods: We developed a rabbit model of SMC-rich atherosclerotic plaque with various degree of stenosis induced by incomplete ligation and generated three-dimensional models of five rabbit femoral arteries based on 130-162 serial histological cross-sections at 100-μm intervals per artery. We performed a computational blood flow simulation using the Reynolds-averaged Navier-Stokes model and calculated the wall shear stress (WSS), turbulence kinetic energy (TKE), blood pressure (BP) and blood pressure gradients (BPG) in eight sections (the inlet, the stenotic portion and areas 1, 2 and 5mm from the stenotic portion) in each rabbit. We also investigated whether the magnitude of WSS or TKE was related to the presence or absence of erosive injury by evaluating six points (the locally highest, median and lowest of WSS or TKE) in each section.\nResults: The magnitudes of WSS, TKE and BPG, but not BP, correlated significantly with the extent of histologically-defined plaque erosion (WSS, r=0.55, p<0.001; TKE, r=0.53, p<0.001; BPG, r=0.61, p<0.0001, n=40). The values for WSS and TKE were significantly larger at sites with, compared to without, erosive injury (n=107 and n=119 points, respectively; both p<0.0001).\nConclusions: These results suggest that increased values of WSS, TKE and BPG considerably contribute to the onset of plaque erosion.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"医博甲第420号"}]},"item_10006_relation_16":{"attribute_name":"他の資源との関係","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://hdl.handle.net/10458/4967"}]}]},"item_10006_textarea_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"本論文に関連する研究論文\nSameshima N, Yamashita A, Sato S, Matsuda S, Matsuura Y, Asada Y. The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits. J Atheroscler Thromb. 2014;21(8):831-8. doi: 10.5551/jat.23093. Epub 2014 Mar 25. PMID: 24671111."}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sameshima, Naoki","creatorNameLang":"en"},{"creatorName":"鮫島, 直樹","creatorNameLang":"ja"},{"creatorName":"サメシマ, ナオキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"filename":"A420Yhakuron.pdf","filesize":[{"value":"58.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文要旨","objectType":"abstract","url":"https://miyazaki-u.repo.nii.ac.jp/record/3869/files/A420Yhakuron.pdf"},"version_id":"7c11a096-f93c-48a9-8078-d9060882439f"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"filename":"A420Yshinsa.pdf","filesize":[{"value":"58.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"学位論文審査結果の要旨","objectType":"other","url":"https://miyazaki-u.repo.nii.ac.jp/record/3869/files/A420Yshinsa.pdf"},"version_id":"aff5e374-aa8b-4c24-a3d0-febe4b2ad6cc"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"filename":"A420Honbun.pdf","filesize":[{"value":"723.7 kB"}],"format":"application/pdf","licensefree":"本論文の著作権は日本動脈硬化学会が保持しています。","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"博士学位論文","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/3869/files/A420Honbun.pdf"},"version_id":"4a729476-9f32-45f4-a10f-4cffdb004659"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Plaque erosion, Animal model, Computational fluid dynamics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits","subitem_title_language":"en"},{"subitem_title":"動脈硬化巣におけるびらん性傷害に関与する血行力学的因子の検討 : 家兎動脈硬化モデルでのコンピューターシュミレーション解析","subitem_title_language":"ja"}]},"item_type_id":"10006","owner":"9","path":["72","54"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-09-03"},"publish_date":"2014-09-03","publish_status":"0","recid":"3869","relation_version_is_last":true,"title":["The values of wall shear stress, turbulence kinetic energy and blood pressure gradient are associated with atherosclerotic plaque erosion in rabbits"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2024-02-09T07:57:15.828854+00:00"}