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腹部大動脈瘤形成におけるアドレノメデュリンの役割
http://hdl.handle.net/10458/4934
http://hdl.handle.net/10458/4934a11f0cb1-8a96-4796-871e-6c8c8995e799
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論文要旨 (54.4 kB)
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学位論文審査結果の要旨 (62.5 kB)
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博士学位論文 (614.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2014-08-01 | |||||
| タイトル | ||||||
| タイトル | Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice | |||||
| 言語 | en | |||||
| タイトル | ||||||
| タイトル | 腹部大動脈瘤形成におけるアドレノメデュリンの役割 | |||||
| 言語 | ja | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Aneurysm, Angiotensin II, Aortic Rupture | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| 著者 |
坂元, 紀陽
× 坂元, 紀陽 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abdominal aortic aneurysm (AAA) develops based on advanced atherosclerosis; however, the underlying pathogenesis remains unknown. Adrenomedullin (AM) is widely expressed in various human and rodent tissues, and has been reported to protect blood vessels. We have previously reported that AM is produced in mast cells of human AAA and that AM exhibited the antifibrotic activity of mast cell-derived AM on fibroblasts. In the present study, we investigated the role of AM in the development of AAA in 12-week-old male apolipoprotein (apo)E﹣/﹣ mice bred with AM heterozygous, or its role when recombinant human (rh) AM was administrated to the apoE﹣/﹣ male mice, which was infused with 1000 ng/kg/min of angiotensin II (Ang II) for 28 days. The incidence of the development of AAA in Ang II-infused apoE﹣/﹣ AM﹢/﹣ mice did not change compared with that in apoE﹣/﹣ mice (33.3% vs. 47.4%, p = 0.2333). In addition, rhAM administration had little effect on the incidence of the development of AAA formation (AM: 0 ng/kg/hr 47.4%; 300 ng/kg/hr 36.4%; 3000 ng/kg/hr 27.3%; p = 0.2595). In conclusion, this study suggests that AM does not contribute toward the development of AAA. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 言語 | ja | |||||
| 値 | 本論文に関連する研究論文 Sakamoto, S. , Tsuruda, T. , Hatakeyama, K. , Shimosawa, T. , Asada, Y. and Kitamura, K. (2014) Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice. Health, 6, 1077-1084. doi: 10.4236/health.2014.610133. |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17601 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 宮崎大学 | |||||
| 学位授与年度 | ||||||
| 内容記述 | 2014年度 | |||||
| 言語 | ja | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2014-06-24 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 医博甲第421号 | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://hdl.handle.net/10458/4935 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| リンク |
Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice
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