WEKO3
-
RootNode
アイテム
Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice
http://hdl.handle.net/10458/4935
http://hdl.handle.net/10458/4935ab3c1fad-0c02-4bbb-907f-339b1abd96cc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-07-31 | |||||
| タイトル | ||||||
| タイトル | Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Aneurysm, Angiotensin II, Aortic Rupture | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| 著者 |
坂元, 紀陽
× 坂元, 紀陽× 鶴田, 敏博× 畠山, 金太× 下澤, 達雄× 浅田, 祐士郎× 北村, 和雄 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abdominal aortic aneurysm （AAA） develops based on advanced atherosclerosis; however, the underlying pathogenesis remains unknown. Adrenomedullin （AM） is widely expressed in various human and rodent tissues, and has been reported to protect blood vessels. We have previously reported that AM is produced in mast cells of human AAA and that AM exhibited the antifibrotic activity of mast cell-derived AM on fibroblasts. In the present study, we investigated the role of AM in the development of AAA in 12-week-old male apolipoprotein （apo）E﹣/﹣ mice bred with AM heterozygous, or its role when recombinant human （rh） AM was administrated to the apoE﹣/﹣ male mice, which was infused with 1000 ng/kg/min of angiotensin II （Ang II） for 28 days. The incidence of the development of AAA in Ang II-infused apoE﹣/﹣ AM﹢/﹣ mice did not change compared with that in apoE﹣/﹣ mice （33.3% vs. 47.4%, p = 0.2333）. In addition, rhAM administration had little effect on the incidence of the development of AAA formation （AM: 0 ng/kg/hr 47.4%; 300 ng/kg/hr 36.4%; 3000 ng/kg/hr 27.3%; p = 0.2595）. In conclusion, this study suggests that AM does not contribute toward the development of AAA. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : Health 巻 6, 号 10, p. 1077-1084, 発行日 2014-04 |
|||||
| 出版者 | ||||||
| 出版者 | Scientific Research | |||||
| 言語 | en | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.4236/health.2014.610133 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | (C) 2014 by authors and Scientific Research Publishing Inc. | |||||
| 他の資源との関係 | ||||||
| 関連名称 | http://hdl.handle.net/10458/4934 | |||||
Share
Cite as
坂元, 紀陽, 鶴田, 敏博, 畠山, 金太, 下澤, 達雄, 浅田, 祐士郎, 北村, 和雄, 2014, Adrenomedullin Does Not Contribute toward the Development of Abdominal Aortic Aneurysm in Mice: Scientific Research, 1077–1084 p.
Loading...
