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Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by in Vitro Stimulation Due to the Induction of CCR5
http://hdl.handle.net/10458/3246
http://hdl.handle.net/10458/32463b8a0121-6f8c-4b60-a0bc-f95ecfbecea4
名前 / ファイル | ライセンス | アクション |
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3246haga.pdf (382.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-18 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by in Vitro Stimulation Due to the Induction of CCR5 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
キーワード | CCR5, CD4 and CD8 double-positive T cells, Simian Immunodeficiency Virus | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Matsumoto, Yusuke
× Matsumoto, Yusuke× Miura, Tomoyuki× Akari, Hirofumi× Goto, Yoshitaka× Haga, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In vivo Simian Immunodeficiency Virus (SIV) challenge of macaques demonstrated the earlier disappearance of CD4 and CD8 double-positive (DP) T cells than CD4 single-positive T cells, although its mechanism remains unclear. Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal antibodies. Activated DP T cells were more vulnerable to SIV infection, indicating that the ability of DP T cells to readily express CCR5 after activation may hasten DP T cell death by SIV infection in vivo. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of veterinary medical science en : J. vet. med. sci 巻 72, 号 8, p. 1057-1061, 発行日 2010-08 |
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出版者 | ||||||
言語 | en | |||||
出版者 | Japanese Society of Veterinary Science | |||||
出版者 | ||||||
言語 | ja | |||||
出版者 | 日本獣医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10796138 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 20224239 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |