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Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by in Vitro Stimulation Due to the Induction of CCR5
http://hdl.handle.net/10458/3246
http://hdl.handle.net/10458/32463b8a0121-6f8c-4b60-a0bc-f95ecfbecea4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
3246haga.pdf (382.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-18 | |||||
| タイトル | ||||||
| タイトル | Peripheral Blood CD4 and CD8 Double-Positive T Cells of Rhesus Macaques Become Vulnerable to Simian Immunodeficiency Virus by in Vitro Stimulation Due to the Induction of CCR5 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | CCR5, CD4 and CD8 double-positive T cells, Simian Immunodeficiency Virus | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Matsumoto, Yusuke
× Matsumoto, Yusuke× Miura, Tomoyuki× Akari, Hirofumi× Goto, Yoshitaka× Haga, Takeshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In vivo Simian Immunodeficiency Virus （SIV） challenge of macaques demonstrated the earlier disappearance of CD4 and CD8 double-positive （DP） T cells than CD4 single-positive T cells, although its mechanism remains unclear. Here we found that peripheral DP T cells were readily induced to express CCR5, a secondary receptor for SIV, by in vitro stimulation with either concanavalin A or anti-CD3/CD28 monoclonal antibodies. Activated DP T cells were more vulnerable to SIV infection, indicating that the ability of DP T cells to readily express CCR5 after activation may hasten DP T cell death by SIV infection in vivo. | |||||
| 言語 | en | |||||
| 書誌情報 |
en : The journal of veterinary medical science en : J. vet. med. sci 巻 72, 号 8, p. 1057-1061, 発行日 2010-08 |
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| 出版者 | ||||||
| 出版者 | Japanese Society of Veterinary Science | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | 日本獣医学会 | |||||
| 言語 | ja | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09167250 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA10796138 | |||||
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| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20224239 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
