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Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)
http://hdl.handle.net/10458/1132
http://hdl.handle.net/10458/113213f7d540-7c3e-4d7b-b866-3f0a8a130e76
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
VascPharmacol47_166.pdf (184.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-01-30 | |||||
| タイトル | ||||||
| タイトル | Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| キーワード | Endothelium, Hypercholesterolemia, Mice (Apodemus sylvaticus), Nitric oxide, Vascular reactivity | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
伊藤, 勝昭
× 伊藤, 勝昭× 伊藤, 薫× Ito, Kaoru M.× Okayasu, Misao× 越本, 知大× 篠原, 明男× 浅田, 祐士郎× 土屋, 公幸× Sakamoto, Takumi× 伊藤, 勝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We evaluated endothelial function of thoracic aortas and pulmonary arteries in a population of European wood mice （Apodemus sylvaticus）, which exhibits hypercholesteromia. According to the plasma cholesterol level, mice were divided into two groups: hypercholesterolemic （AHL, total plasma cholesterol 200-300 mg/dl） and normocholesterolemic （ANL, total plasma cholesterol <200 mg/dl）. Acetylcholine （ACh） caused endothelium-dependent relaxation of precontracted aortas and pulmonary arteries. Relaxation of the pulmonary artery is completely dependent on nitric oxide. This relaxation was inhibited in AHL pulmonary arteries. On the other hand, part of the ACh-induced relaxation of the thoracic aorta was resistant to Nω-nitro-L-arginine （L-NNA）. L-NNA-sensitive and -resistant relaxation to ACh were also inhibited in AHL aortas. Inhibition of endothelium-dependent relaxation of the aortas was correlated with total plasma cholesterol level. Endothelium-independent relaxation to sodium nitroprusside （SNP） was similar in AHL and ANL pulmonary arteries, but in the thoracic aorta of AHL mice, the sensitivity to SNP was slightly decreased, without a change in maximal response to SNP. No morphological change was observed in the aortas and the pulmonary arteries from AHL and ANL mice. Thus, AHL mice are valuable as a new experimental model to study the relation of hyperlipidemia to vascular disease since the endothelial function is impaired in these mild hyperlipidemic animals. |
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| 言語 | en | |||||
| 書誌情報 |
en : Vascular pharmacology 巻 47, 号 2-3, p. 166-173, 発行日 2007-08 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 15371891 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11703926 | |||||
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| 出版タイプ | AM | |||||
