{"created":"2023-05-15T09:56:38.445441+00:00","id":270,"links":{},"metadata":{"_buckets":{"deposit":"a8dd750f-c6a0-4179-bc86-459b040a7e14"},"_deposit":{"created_by":5,"id":"270","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"270"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:00000270","sets":["74","74:26"]},"author_link":["7742","1111","1071","2792","1116","5169","1110","1117","1112"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-3","bibliographicPageEnd":"173","bibliographicPageStart":"166","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Vascular pharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We evaluated endothelial function of thoracic aortas and pulmonary arteries\nin a population of European wood mice （Apodemus sylvaticus）, which\nexhibits hypercholesteromia. According to the plasma cholesterol level,\nmice were divided into two groups: hypercholesterolemic （AHL, total\nplasma cholesterol 200-300 mg/dl） and normocholesterolemic （ANL, total\nplasma cholesterol <200 mg/dl）. Acetylcholine （ACh） caused\nendothelium-dependent relaxation of precontracted aortas and pulmonary\narteries. Relaxation of the pulmonary artery is completely dependent on\nnitric oxide. This relaxation was inhibited in AHL pulmonary arteries.\nOn the other hand, part of the ACh-induced relaxation of the thoracic aorta\nwas resistant to Nω-nitro-L-arginine （L-NNA）. L-NNA-sensitive and\n-resistant relaxation to ACh were also inhibited in AHL aortas. Inhibition\nof endothelium-dependent relaxation of the aortas was correlated with total\nplasma cholesterol level. Endothelium-independent relaxation to sodium\nnitroprusside （SNP） was similar in AHL and ANL pulmonary arteries, but\nin the thoracic aorta of AHL mice, the sensitivity to SNP was slightly\ndecreased, without a change in maximal response to SNP. No\nmorphological change was observed in the aortas and the pulmonary\narteries from AHL and ANL mice. Thus, AHL mice are valuable as a new\nexperimental model to study the relation of hyperlipidemia to vascular\ndisease since the endothelial function is impaired in these mild\nhyperlipidemic animals.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11703926","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15371891","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 勝昭","creatorNameLang":"ja"},{"creatorName":"イトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Katsuaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 薫","creatorNameLang":"ja"},{"creatorName":"イトウ, カオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Kaoru M.","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okayasu, Misao","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Koshimoto, Chihiro","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Shinohara, Akio","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Asada, Yujiro","creatorNameLang":"en"},{"creatorName":"浅田, 祐士郎","creatorNameLang":"ja"},{"creatorName":"アサダ　, ユウジロウ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Tsuchiya, Kimiyuki","creatorNameLang":"en"},{"creatorName":"土屋, 公幸","creatorNameLang":"ja"},{"creatorName":"ツチヤ, キミユキ","creatorNameLang":"ja-Kana"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Takumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊藤, 勝昭","creatorNameLang":"ja"},{"creatorName":"イトウ, カツアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Katsuaki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-06-21"}],"displaytype":"detail","filename":"VascPharmacol47_166.pdf","filesize":[{"value":"184.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"VascPharmacol47_166.pdf","url":"https://miyazaki-u.repo.nii.ac.jp/record/270/files/VascPharmacol47_166.pdf"},"version_id":"3c0a1f70-7dff-42ed-b239-fd92fc26c578"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Endothelium, Hypercholesterolemia, Mice (Apodemus sylvaticus), Nitric oxide, Vascular reactivity","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["74","26"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2008-01-30"},"publish_date":"2008-01-30","publish_status":"0","recid":"270","relation_version_is_last":true,"title":["Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)"],"weko_creator_id":"5","weko_shared_id":2},"updated":"2023-10-22T07:54:35.358096+00:00"}