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Optimization of inhaled anesthesia for Octodon degus using electroencephalography
http://hdl.handle.net/10458/0002000887
http://hdl.handle.net/10458/000200088758065859-85c1-48d7-bf1a-6a587d40a4a5
| 名前 / ファイル | ライセンス | アクション |
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本文 (858 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2025-01-20 | |||||||
| タイトル | ||||||||
| タイトル | Optimization of inhaled anesthesia for Octodon degus using electroencephalography | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | animal welfare | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | degu | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | isoflurane | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | refinement | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | sevoflurane | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| 著者 |
Ikai, Yuki
× Ikai, Yuki
× 名倉, 悟郎× 坂本, 信介× 篠原, 明男× 越本, 知大 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Physiological responses to inhaled anesthetics vary among species. Therefore, a precise anesthetic technique is important for each individual species. In this study, we focused on the degu (Octodon degus), a small herbivorous rodent. Degus have recently begun to be used as laboratory models for brain research because of certain human-like characteristics, such as spontaneous development of Alzheimer’s disease. In this study, we evaluated appropriate induction and maintenance anesthesia conditions for isoflurane and sevoflurane in degus by a stimulation test, electroencephalography (EEG), minimum alveolar concentration (MAC), and vital signs. During induction, more rapid time to loss of the righting reflex and deeper anesthesia in degus were observed in isoflurane. The MAC value for degus were 1.75 ± 0.0% in isoflurane and 2.25 ± 0.27% in sevoflurane. Whereas some degus were awake during maintenance anesthesia using both anesthetics at concentrations of ≤2%, no rats were awake when using sevoflurane at a concentration of 2%. The duration of the total flat EEG, a measure of the depth of maintenance anesthesia, was longer for isoflurane than for sevoflurane. Furthermore, higher concentrations of both anesthetics suppressed the respiratory rate in degus. These new findings regarding inhalation anesthesia in degus will contribute to future developments in the fields of laboratory animals and veterinary medicine. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Yuki Ikai, Goro A. Nagura-Kato, Shinsuke H. Sakamoto, Akio Shinohara, Chihiro Koshimoto, Optimization of inhaled anesthesia for Octodon degus using electroencephalography, Experimental Animals, 74(1), 93-103, 2025, https://doi.org/10.1538/expanim.24-0017 | |||||||
| 言語 | en | |||||||
| 書誌情報 |
en : Experimental Animals 巻 74, 号 1, p. 93-103 |
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| 出版者 | ||||||||
| 出版者 | Japanese Association for Laboratory Animal Science | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 1341-1357 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1881-7122 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1538/expanim.24-0017 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報Resource | © 2025 Japanese Association for Laboratory Animal Science | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
