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Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma
http://hdl.handle.net/10458/0002000868
http://hdl.handle.net/10458/0002000868ff3fd2ae-cea3-4cbe-b668-88dc4903ce94
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2024-12-24 | |||||||
| タイトル | ||||||||
| タイトル | Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | BMP | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | GREM2 | |||||||
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| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | Induced calcification | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | Malignant meningioma | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | Senescence | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| 著者 |
横上, 聖貴
× 横上, 聖貴× Watanabe, Takashi
× 山下, 真治× 水口, 麻子× 竹島, 秀雄 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | PURPOSE Meningiomas are the most common type of brain tumors and are generally benign, but malignant atypical meningiomas and anaplastic meningiomas frequently recur with poor prognosis. The metabolism of meningiomas is little known, so few effective treatment options other than surgery and radiation are available, and the targets for treatment of recurrence are not well defined. The Aim of this paper is to find the therapeutic target. METHODS The effects of bone morphogenetic protein (BMP) signal inhibitor (K02288) and upstream regulator Gremlin2 (GREM2) on meningioma's growth and senescence were examined. In brief, we examined as follows: 1) Proliferation assay by inhibiting BMP signaling. 2) Comprehensive analysis of forced expression GREM2.3) Correlation between GREM2 mRNA expression and proliferation marker in 87 of our clinical samples. 4) Enrichment analysis between GREM2 high/low expressed groups using RNA-seq data (42 cases) from the public database GREIN. 5) Changes in metabolites and senescence markers associated with BMP signal suppression. RESULTS Inhibitors of BMP receptor (BMPR1A) and forced expression of GREM2 shifted tryptophan metabolism from kynurenine/quinolinic acid production to serotonin production in malignant meningiomas, reduced NAD + /NADH production, decreased gene cluster expression involved in oxidative phosphorylation, and caused decrease in ATP. Finally, malignant meningiomas underwent cellular senescence, decreased proliferation, and eventually formed psammoma bodies. Reanalyzed RNA-seq data of clinical samples obtained from GREIN showed that increased expression of GREM2 decreased the expression of genes involved in oxidative phosphorylation, similar to our experimental results. CONCLUSIONS The GREM2-BMPR1A-tryptophan metabolic pathway in meningiomas is a potential new therapeutic target. |
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| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Yokogami, K., Watanabe, T., Yamashita, S. et al. Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma. J Neurooncol 167, 455–465 (2024). https://doi.org/10.1007/s11060-024-04625-2 |
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| 言語 | en | |||||||
| 書誌情報 |
en : Journal of Neuro-Oncology 巻 167, 号 3, p. 455-465, 発行日 2024-03-06 |
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| 出版者 | ||||||||
| 出版者 | Springer Science and Business Media LLC | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0167-594X | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1573-7373 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1007/s11060-024-04625-2 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報Resource | © Springer Science+Business Media, LLC, part of Springer Nature 2024 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
