{"created":"2024-12-24T06:32:51.410817+00:00","id":2000868,"links":{},"metadata":{"_buckets":{"deposit":"4c32f30b-536f-4f93-9a13-89a2438b448e"},"_deposit":{"created_by":9,"id":"2000868","owner":"9","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000868"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000868","sets":["72","72:30"]},"author_link":["34673","34658","34646","32351"],"item_10001_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"465","bibliographicPageStart":"455","bibliographicVolumeNumber":"167","bibliographic_titles":[{"bibliographic_title":"Journal of Neuro-Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE\nMeningiomas are the most common type of brain tumors and are generally benign, but malignant atypical meningiomas and anaplastic meningiomas frequently recur with poor prognosis. The metabolism of meningiomas is little known, so few effective treatment options other than surgery and radiation are available, and the targets for treatment of recurrence are not well defined. The Aim of this paper is to find the therapeutic target.\nMETHODS\nThe effects of bone morphogenetic protein (BMP) signal inhibitor (K02288) and upstream regulator Gremlin2 (GREM2) on meningioma's growth and senescence were examined. In brief, we examined as follows: 1) Proliferation assay by inhibiting BMP signaling. 2) Comprehensive analysis of forced expression GREM2.3) Correlation between GREM2 mRNA expression and proliferation marker in 87 of our clinical samples. 4) Enrichment analysis between GREM2 high/low expressed groups using RNA-seq data (42 cases) from the public database GREIN. 5) Changes in metabolites and senescence markers associated with BMP signal suppression.\nRESULTS\nInhibitors of BMP receptor (BMPR1A) and forced expression of GREM2 shifted tryptophan metabolism from kynurenine/quinolinic acid production to serotonin production in malignant meningiomas, reduced NAD + /NADH production, decreased gene cluster expression involved in oxidative phosphorylation, and caused decrease in ATP. Finally, malignant meningiomas underwent cellular senescence, decreased proliferation, and eventually formed psammoma bodies. Reanalyzed RNA-seq data of clinical samples obtained from GREIN showed that increased expression of GREM2 decreased the expression of genes involved in oxidative phosphorylation, similar to our experimental results.\nCONCLUSIONS\nThe GREM2-BMPR1A-tryptophan metabolic pathway in meningiomas is a potential new therapeutic target.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nYokogami, K., Watanabe, T., Yamashita, S. et al. Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma. J Neurooncol 167, 455–465 (2024). https://doi.org/10.1007/s11060-024-04625-2","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Science and Business Media LLC","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"item_10001_relation_14","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s11060-024-04625-2","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Springer Science+Business Media, LLC, part of Springer Nature 2024","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0167-594X","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"1573-7373","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"横上, 聖貴","creatorNameLang":"ja"},{"creatorName":"ヨコガミ, キヨタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokogami, Kiyotaka","creatorNameLang":"en"}],"familyNames":[{"familyName":"横上","familyNameLang":"ja"},{"familyName":"ヨコガミ","familyNameLang":"ja-Kana"},{"familyName":"Yokogami","familyNameLang":"en"}],"givenNames":[{"givenName":"聖貴","givenNameLang":"ja"},{"givenName":"キヨタカ","givenNameLang":"ja-Kana"},{"givenName":"Kiyotaka","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34673","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40284856","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40284856"}]},{"creatorNames":[{"creatorName":"Watanabe, Takashi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"山下, 真治","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Shinji","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"真治","givenNameLang":"ja"},{"givenName":"シンジ","givenNameLang":"ja-Kana"},{"givenName":"Shinji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34658","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40468046","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40468046"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"水口, 麻子","creatorNameLang":"ja"},{"creatorName":"ミズグチ, アサコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mizuguchi, Asako","creatorNameLang":"en"}],"familyNames":[{"familyName":"水口","familyNameLang":"ja"},{"familyName":"ミズグチ","familyNameLang":"ja-Kana"},{"familyName":"Mizuguchi","familyNameLang":"en"}],"givenNames":[{"givenName":"麻子","givenNameLang":"ja"},{"givenName":"アサコ","givenNameLang":"ja-Kana"},{"givenName":"Asako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"34646","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00647472","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=00647472"}]},{"creatorNames":[{"creatorName":"Takeshima, Hideo","creatorNameLang":"en"},{"creatorName":"竹島, 秀雄","creatorNameLang":"ja"},{"creatorName":"タケシマ, ヒデオ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Takeshima","familyNameLang":"en"},{"familyName":"竹島","familyNameLang":"ja"},{"familyName":"タケシマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hideo","givenNameLang":"en"},{"givenName":"秀雄","givenNameLang":"ja"},{"givenName":"ヒデオ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"32351","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70244134","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70244134"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","format":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://link.springer.com/content/pdf/10.1007/s11060-024-04625-2.pdf"}}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GREM2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Induced calcification","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Malignant meningioma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Senescence","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["72","30"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-24"},"publish_date":"2024-12-24","publish_status":"0","recid":"2000868","relation_version_is_last":true,"title":["Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-06-01T23:51:32.104854+00:00"}