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Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model
http://hdl.handle.net/10458/0002000698
http://hdl.handle.net/10458/000200069828a0d983-179e-4a9d-93d9-f8b19cdc7114
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2024-08-20 | |||||||
| タイトル | ||||||||
| タイトル | Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | body-weight gain | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | diclazuril | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | Eimeria vermiformis | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | host immunity | |||||||
| キーワード | ||||||||
| 言語 | en | |||||||
| 主題Scheme | Other | |||||||
| キーワード | toltrazuril | |||||||
| 資源タイプ | ||||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| 著者 |
Ahmadi, Parnian
× Ahmadi, Parnian
× バクタリ, マハマウド× 保田, 昌宏× 野中, 成晃× 吉田, 彩子 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Intestinal coccidiosis caused by Eimeria protozoan species is an economically important disease, especially in poultry and cattle. Anti-coccidial drugs commonly used for controlling coccidiosis are toltrazuril (TTZ) and diclazuril (DCZ). In this study, the efficacies of TTZ and DCZ were compared using a murine model, and the effect of these treatments on the induction of acquired resistance was evaluated. Male C57BL/6J mice were inoculated with 1,000 sporulated E. vermiformis oocytes and treated with TTZ or DCZ. The recommended TTZ dose for cattle (15 mg/kg) completely prevented oocyte excretion. But, mice required 5 mg/kg of DCZ, which is five times the recommended dose for cattle, to reduce oocyte excretion. In E. vermiformis re-infection, TTZ (15 mg/kg) and DCZ (5 mg/kg) treatments did not interfere with the development of acquired resistance. Bodyweight gain was significantly higher in the TTZ-treated group than in the control (untreated/infected) group and the DCZ-treated group, and no significant difference in bodyweight gain was observed between the TTZ-treated group and the healthy (uninfected/untreated) group. Analysis of T lymphocyte subsets in the spleen and mesenteric lymph nodes indicated that the relative populations of CD4+ and CD8+ T cells were reduced in the DCZ-treated and control (untreated/infected) groups, suggesting there was immunosuppression during the infection. However, no reductions in T cell populations were observed in the TTZ-treated group. The results indicated that an optimal anti-coccidial drug is one that can completely break the parasite life cycle in the host animal. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | Citation: Ahmadi P, Baakhtari M, Yasuda M, Nonaka N, Yoshida A. Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model. J Vet Med Sci. 2022 Sep 21;84(10):1345-1351. doi: 10.1292/jvms.22-0136 |
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| 言語 | en | |||||||
| 書誌情報 |
en : Journal of Veterinary Medical Science 巻 84, 号 10, p. 1345-1351, 発行日 2022 |
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| 出版者 | ||||||||
| 出版者 | Japanese Society of Veterinary Science | |||||||
| 言語 | en | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0916-7250 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1347-7439 | |||||||
| DOI | ||||||||
| 関連タイプ | isVersionOf | |||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1292/jvms.22-0136 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | © 2022 by the Japanese Society of Veterinary Science | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
