{"created":"2024-08-20T06:51:54.731978+00:00","id":2000698,"links":{},"metadata":{"_buckets":{"deposit":"088e9789-8fd6-42bf-b188-e4341fbda1fc"},"_deposit":{"created_by":9,"id":"2000698","owner":"5","owners":[9],"pid":{"revision_id":0,"type":"depid","value":"2000698"},"status":"published"},"_oai":{"id":"oai:miyazaki-u.repo.nii.ac.jp:02000698","sets":["76","76:64"]},"author_link":["2737","21732","34853","27924"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1351","bibliographicPageStart":"1345","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"Journal of Veterinary Medical Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intestinal coccidiosis caused by Eimeria protozoan species is an economically important disease, especially in poultry and cattle. Anti-coccidial drugs commonly used for controlling coccidiosis are toltrazuril (TTZ) and diclazuril (DCZ). In this study, the efficacies of TTZ and DCZ were compared using a murine model, and the effect of these treatments on the induction of acquired resistance was evaluated. Male C57BL/6J mice were inoculated with 1,000 sporulated E. vermiformis oocytes and treated with TTZ or DCZ. The recommended TTZ dose for cattle (15 mg/kg) completely prevented oocyte excretion. But, mice required 5 mg/kg of DCZ, which is five times the recommended dose for cattle, to reduce oocyte excretion. In E. vermiformis re-infection, TTZ (15 mg/kg) and DCZ (5 mg/kg) treatments did not interfere with the development of acquired resistance. Bodyweight gain was significantly higher in the TTZ-treated group than in the control (untreated/infected) group and the DCZ-treated group, and no significant difference in bodyweight gain was observed between the TTZ-treated group and the healthy (uninfected/untreated) group. Analysis of T lymphocyte subsets in the spleen and mesenteric lymph nodes indicated that the relative populations of CD4+ and CD8+ T cells were reduced in the DCZ-treated and control (untreated/infected) groups, suggesting there was immunosuppression during the infection. However, no reductions in T cell populations were observed in the TTZ-treated group. The results indicated that an optimal anti-coccidial drug is one that can completely break the parasite life cycle in the host animal.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Citation:\nAhmadi P, Baakhtari M, Yasuda M, Nonaka N, Yoshida A. Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model. J Vet Med Sci. 2022 Sep 21;84(10):1345-1351. doi: 10.1292/jvms.22-0136","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese Society of Veterinary Science","subitem_publisher_language":"en"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.22-0136","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2022 by the Japanese Society of Veterinary Science","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1347-7439","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ahmadi, Parnian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Baakhtari, Mahmoud","creatorNameLang":"en"},{"creatorName":"バクタリ, マハマウド","creatorNameLang":"ja"},{"creatorName":"バクタリ, マハマウド","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Baakhtari","familyNameLang":"en"},{"familyName":"バクタリ","familyNameLang":"ja"},{"familyName":"バクタリ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Mahmoud","givenNameLang":"en"},{"givenName":"マハマウド","givenNameLang":"ja"},{"givenName":"マハマウド","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"34853","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"保田, 昌宏","creatorNameLang":"ja"},{"creatorName":"ヤスダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"保田","familyNameLang":"ja"},{"familyName":"ヤスダ","familyNameLang":"ja-Kana"},{"familyName":"Yasuda","familyNameLang":"en"}],"givenNames":[{"givenName":"昌宏","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2737","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10336290","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10336290"}]},{"creatorNames":[{"creatorName":"野中, 成晃","creatorNameLang":"ja"},{"creatorName":"ノナカ, ナリアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nonaka, Nariaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"野中","familyNameLang":"ja"},{"familyName":"ノナカ","familyNameLang":"ja-Kana"},{"familyName":"Nonaka","familyNameLang":"en"}],"givenNames":[{"givenName":"成晃","givenNameLang":"ja"},{"givenName":"ナリアキ","givenNameLang":"ja-Kana"},{"givenName":"Nariaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21732","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"0000000106573887","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"https://isni.org/isni/0000000106573887"}],"affiliationNames":[{"affiliationName":"宮崎大学","affiliationNameLang":"ja"},{"affiliationName":"University of Miyazaki","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"吉田, 彩子","creatorNameLang":"ja"},{"creatorName":"ヨシダ, アヤコ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshida, Ayako","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉田","familyNameLang":"ja"},{"familyName":"ヨシダ","familyNameLang":"ja-Kana"},{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"彩子","givenNameLang":"ja"},{"givenName":"アヤコ","givenNameLang":"ja-Kana"},{"givenName":"Ayako","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27924","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20343486","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20343486"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-08-23"}],"filename":"en.pdf","filesize":[{"value":"2.9 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"label":"Fulltext","objectType":"fulltext","url":"https://miyazaki-u.repo.nii.ac.jp/record/2000698/files/en.pdf"},"version_id":"fe92a581-4414-4349-bb88-5e2eb35c6dd6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"body-weight gain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diclazuril","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Eimeria vermiformis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"host immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"toltrazuril","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"9","path":["76","64"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-20"},"publish_date":"2024-08-20","publish_status":"0","recid":"2000698","relation_version_is_last":true,"title":["Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model"],"weko_creator_id":"9","weko_shared_id":-1},"updated":"2025-01-15T04:58:36.302739+00:00"}