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Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats
http://hdl.handle.net/10458/0002000509
http://hdl.handle.net/10458/000200050996c231b5-00d1-48b8-95e7-fc2152258376
| 名前 / ファイル | ライセンス | アクション |
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article (665 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2024-02-22 | |||||||||||||||||
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| タイトル | Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| キーワード | Blood pressure variability | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Noradrenaline | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Azelnidipine | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Hydralazine | |||||||||||||||||
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| 言語 | en | |||||||||||||||||
| キーワード | Baroreceptor reflex sensitivity | |||||||||||||||||
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| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
姜, 丹鳳
× 姜, 丹鳳× Matsuzaki, Minami× 井田, 隆徳
WEKO
1998
× 北村, 和雄
WEKO
7929
× 加藤, 丈司 |
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Increased blood pressure variability (BPV) was shown to be associated with cardiovascular morbidities and/or mortalities. There are various types of BPV depending on time intervals of BP measurements, ranging from beat-to-beat to visit-to-visit or year-to-year. We previously found that continuous infusion of noradrenaline (NA) for 14 days increased short-term BPV every 15 min in rats. The aims of this study were to examine (1) whether NA infusion increases very short-term beat-to-beat BPV, (2) the effects of azelnidipine and hydralazine on NA-induced BPV, and (3) whether baroreceptor reflex sensitivity (BRS) is affected by NA or NA plus those vasodilators. Nine-week-old Wistar rats infused subcutaneously with 30 μg/h NA were orally treated with or without 9.7 mg/day azelnidipine or 5.9 mg/day hydralazine over 14 days. BP levels were continuously monitored via abdominal aortic catheter with a telemetry system in an unrestrained condition. Standard deviations (SDs) were used to evaluate beat-to-beat BPV and BPV every 15 min which was obtained by averaging BP levels for 10-s segment at each time point. BRS was determined by a sequence analysis. Continuous NA infusion over 14 days increased average BP, beat-to-beat BPV, and BPV every 15 min, lowering BRS. Comparing the two vasodilators, hydralazine reduced BP elevation by NA; meanwhile, azelnidipine alleviated BPV augmentation, preserving BRS, despite a smaller BP reduction. Thus, NA infusion increased both very short- and short-term BPV concomitantly with impaired BRS, while azelnidipine had an inhibitory effect, possibly independent of BP-lowering, on those types of BPV and impairment of BRS. | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | Citation: Jiang, D., Matsuzaki, M., Ida, T. et al. Effects of vasodilators on beat-to-beat and every fifteen minutes blood pressure variability induced by noradrenaline infusion in rats. Hypertens Res (2024). https://doi.org/10.1038/s41440-024-01595-w |
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| 言語 | en | |||||||||||||||||
| 書誌情報 |
en : Hypertension Research 発行日 2024-02-09 |
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| 出版者 | Springer Nature | |||||||||||||||||
| 言語 | en | |||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0916-9636 | |||||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1038/s41440-024-01595-w | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | © The Author(s) 2024. | |||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||
